(Tetrahydrofuran-2-ylmethyl)dithiocarbamic acid 3-dimethylcarbamoyl-propyl ester | 370065-37-5

• 分子结构分类: 有机化合物
• 英文名称: (Tetrahydrofuran-2-ylmethyl)dithiocarbamic acid 3-dimethylcarbamoyl-propyl ester
• 英文别名: [4-(dimethylamino)-4-oxobutyl] N-(oxolan-2-ylmethyl)carbamodithioate
• CAS: 370065-37-5
• 化学式: C₁₂H₂₂N₂O₂S₂
• 分子量: 290.451
• InChiKey: IDAMUIYKVDFPGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  99
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• N-substituted Dithiocarbamates for the Treatment of Biological Disorders
  申请人：AtheroGenics, Inc.

  公开号：US20030176496A1

  公开（公告）日：2003-09-18

  Abstract of Disclosure N-substituted dithiocarbamate esters in which the amine function bears a hydrogen are provides, as are methods for using the compounds in the treatment of cellular hyperproliferation and VCAM-1 mediated disease. Particularly provided is a method of treating a hyperproliferative disorder such as cancer comprising administering an antiproliferative agent in combination with a potentiating effective amount of a N-substituted dithiocarbamate ester. Also provided are methods of using the compounds in the treatment of VCAM-1 mediated diseases such as inflammation and carrdiovascular disease.

  本申请提供了氨基功能带有氢的N-取代二硫代氨基甲酸酯化合物，并提供了使用这些化合物治疗细胞增殖过度和VCAM-1介导疾病的方法。特别提供了一种治疗增殖过度性疾病，如癌症的方法，包括在抗增殖剂的基础上与N-取代二硫代氨基甲酸酯的增强有效量联合给药。还提供了使用这些化合物治疗VCAM-1介导疾病，如炎症和心血管疾病的方法。
• N-SUBSTITUTED DITHIOCARBAMATES FOR THE TREATMENT OF BIOLOGICAL DISORDERS
  申请人：Atherogenics, Inc.

  公开号：EP1282445A2

  公开（公告）日：2003-02-12
• US6747061B2
  申请人：——

  公开号：US6747061B2

  公开（公告）日：2004-06-08
• [EN] N-SUBSTITUTED DITHIOCARBAMATES FOR THE TREATMENT OF BIOLOGICAL DISORDERS<br/>[FR] DITHIOCARBAMATES N-SUBSTITUES UTILISES DANS LE TRAITEMENT DE TROUBLES BIOLOGIQUES
  申请人：ATHEROGENICS INC

  公开号：WO2001079164A2

  公开（公告）日：2001-10-25

  Methods and compositions for the treatment of proliferative cell diseases, such as cancer, are provided, using N-substituted dithiocarbamates.