(+/-)-6-(2-hydroxy-2-phenyl-ethylamino)-4-pyridin-4-yl-1H-[1,3,5]triazin-2-one | 1202683-54-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (+/-)-6-(2-hydroxy-2-phenyl-ethylamino)-4-pyridin-4-yl-1H-[1,3,5]triazin-2-one
• 英文别名: 4-[(2-hydroxy-2-phenylethyl)amino]-6-pyridin-4-yl-1H-1,3,5-triazin-2-one
• CAS: 1202683-54-2
• 化学式: C₁₆H₁₅N₅O₂
• 分子量: 309.327
• InChiKey: PDZKSRDFCRKHNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  99
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• 4-(PYRIDIN-4-YL)-1H-[1,3,5]TRIAZIN-2-ONE DERIVATIVES AS GSK3-BETA INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：Mitsubishi Tanabe Pharma Corporation

  公开号：EP2321295A2

  公开（公告）日：2011-05-18
• JP2011525905A
  申请人：——

  公开号：JP2011525905A

  公开（公告）日：2011-09-29
• [EN] SUBSTITUTED TRIAZINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE TRIAZINONE SUBSTITUÉS
  申请人：MITSUBISHI TANABE PHARMA CORP

  公开号：WO2009156860A2

  公开（公告）日：2009-12-30

  A triazinone derivative represented by formula (I) wherein: Z represents a bond, a carbonyl group, a methylene group optionally substituted by one or two groups chosen from a C1-6 alkyl group, a hydroxyl group, a C1-6 alkoxy group; R1 represents a 4-pyridine ring; R2 represents a hydrogen atom, a C1-6 alkyl; R3 represents a hydrogen atom, a C1-6 alkyl group; R2 and R3 may form together a 6 membered cycle with the nitrogens caring R2 and R3 optionally substituted; R4 represents: a phenyl ring, being optionally substituted; n represents 0 to 2; in form of a free base or of an addition salt with an acid. Use in therapeutic.