methyl-2-(2,2,2-trifluoro-ethyl)-1H-benzoimidazole | 1058164-71-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: methyl-2-(2,2,2-trifluoro-ethyl)-1H-benzoimidazole
• 英文别名: 1-Methyl-2-(2,2,2-trifluoroethyl)-1H-benzoimidazole；1-methyl-2-(2,2,2-trifluoroethyl)benzimidazole
• CAS: 1058164-71-8
• 化学式: C₁₀H₉F₃N₂
• 分子量: 214.19
• InChiKey: ZBWPPLQMBFTSOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 三氯氧磷 作用下， 生成 methyl-2-(2,2,2-trifluoro-ethyl)-1H-benzoimidazole
  参考文献：
  名称：

  POCl3-mediated synthesis of hydrolysis-prone 2-trifluoroethylbenzimidazoles

  摘要：

  Loss of a trifluoromethyl group has been observed as an unproductive side reaction in the formation of 2-trifluoroethylbenzimidazoles. A hydrolytic mechanism for this transformation is proposed that is consistent with evidence for the identity of reaction intermediates. Cyclodehydration with POCl3 suppresses hydrolysis of the trifluoromethyl group and provides 2-trifluoroethylbenzimidazoles in good yields. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.06.069

文献信息

• MEDICINAL COMPOSITION FOR INHIBITING AMYLOID- PROTEIN DEPOSITION
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2246334A1

  公开（公告）日：2010-11-03

  The present invention provides: a pharmaceutical composition for inhibiting amyloid-β protein accumulation comprising a compound of the formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient; a method for inhibiting amyloid-β protein accumulation, comprising a step of administering an effective amount of the compound of the formula (I) or a pharmaceutically acceptable salt thereof to a mammal which may be diagnosed with an amyloid-β protein-related disease; and so on.

  本发明提供了：一种用于抑制淀粉样蛋白-β蛋白积累的药物组合物，该组合物包含作为活性成分的式(I)化合物或其药学上可接受的盐；一种抑制淀粉样蛋白-β蛋白积累的方法，该方法包括向可能被诊断患有淀粉样蛋白-β蛋白相关疾病的哺乳动物施用有效量的式(I)化合物或其药学上可接受的盐的步骤；等等。