(S)-5-(benzyloxy)-1,1,1-trifluoro-5-methyl-2-(naphthalen-3-yl)hex-3-yn-2-ol | 1255152-67-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (S)-5-(benzyloxy)-1,1,1-trifluoro-5-methyl-2-(naphthalen-3-yl)hex-3-yn-2-ol
• 英文别名: (2S)-1,1,1-trifluoro-5-methyl-2-naphthalen-2-yl-5-phenylmethoxyhex-3-yn-2-ol
• CAS: 1255152-67-0
• 化学式: C₂₄H₂₁F₃O₂
• 分子量: 398.425
• InChiKey: JOQZQLPEVYOXRZ-HSZRJFAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (S)-5-(benzyloxy)-1,1,1-trifluoro-5-methyl-2-(naphthalen-3-yl)hex-3-yn-2-ol 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 6.0h， 以100%的产率得到(S)-1,1,1-trifluoro-5-methyl-2-(naphthalen-3-yl)hex-3-yne-2,5-diol
  参考文献：
  名称：

  Cinchona Alkaloid-Catalyzed Asymmetric Trifluoromethylation of Alkynyl Ketones with Trimethylsilyl Trifluoromethane

  摘要：

  The first catalytic enantioselective trifluoromethylation of alkynyl ketones 1 with (trifluoromethyl)trimethylsilane is disclosed by an operationally simple procedure, based on the combination of ammonium bromide of bis-cinchona alkaloids with Me4NF to afford trifluoromethyl-substituted tertiary propargyl alcohols (up to 96% ee), which are the important chiral building blocks for pharmaceuticals. Biologically attractive aryl heteroaryl trifluoromethyl carbinols were also synthesized.

  DOI：

  10.1021/ol102189c
• 作为产物：
  描述：

  4-(benzyloxy)-4-methyl-1-(naphthalen-3-yl)pent-2-yn-1-one 、 (三氟甲基)三甲基硅烷 在 2Br^(1-)*C₄₆H₅₂N₄O₂⁽²⁺⁾ 、 四甲基氟化铵 、 四丁基氟化铵 作用下， 以 二氯甲烷 、 甲苯 、 四氢呋喃 为溶剂， 反应 3.0h， 生成 (S)-5-(benzyloxy)-1,1,1-trifluoro-5-methyl-2-(naphthalen-3-yl)hex-3-yn-2-ol 、 (R)-5-(benzyloxy)-1,1,1-trifluoro-5-methyl-2-(naphthalen-3-yl)hex-3-yn-2-ol
  参考文献：
  名称：

  Cinchona Alkaloid-Catalyzed Asymmetric Trifluoromethylation of Alkynyl Ketones with Trimethylsilyl Trifluoromethane

  摘要：

  The first catalytic enantioselective trifluoromethylation of alkynyl ketones 1 with (trifluoromethyl)trimethylsilane is disclosed by an operationally simple procedure, based on the combination of ammonium bromide of bis-cinchona alkaloids with Me4NF to afford trifluoromethyl-substituted tertiary propargyl alcohols (up to 96% ee), which are the important chiral building blocks for pharmaceuticals. Biologically attractive aryl heteroaryl trifluoromethyl carbinols were also synthesized.

  DOI：

  10.1021/ol102189c