tert-butyldiphenyl((18Z,21Z,24Z)-12-(phenylsulfonyl)triaconta-18,21,24-trienyloxy)silane | 1260225-90-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyldiphenyl((18Z,21Z,24Z)-12-(phenylsulfonyl)triaconta-18,21,24-trienyloxy)silane
• 英文别名: [(18Z,21Z,24Z)-12-(benzenesulfonyl)triaconta-18,21,24-trienoxy]-tert-butyl-diphenylsilane
• CAS: 1260225-90-8
• 化学式: C₅₂H₇₈O₃SSi
• 分子量: 811.341
• InChiKey: VOMMEPDRZMTRJR-YOILPLPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.29
• 重原子数：
  57
• 可旋转键数：
  32
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tert-butyldiphenyl((18Z,21Z,24Z)-12-(phenylsulfonyl)triaconta-18,21,24-trienyloxy)silane 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以99%的产率得到(18Z,21Z,24Z)-12-(phenylsulfonyl)triaconta-18,21,24-trien-1-ol
  参考文献：
  名称：

  Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids

  摘要：

  First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, 34:5n5, and three other unlabeled very long chain C30-32 containing polyunsaturated fatty acids are reported. These syntheses were achieved by coupling chemically modified C22- and C20-containing polyunsaturated fatty acids with carbanions derived from arylalkyl sulfones, followed by sodium amalgam-mediated desulfonylation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.139
• 作为产物：
  描述：

  (6Z,9Z,12Z)-octadeca-6,9,12-trien-1-yl 4-methylbenzenesulfonate 、 tert-butyldiphenyl(12-(phenylsulfonyl)dodecyloxy)silane 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 12.5h， 以62%的产率得到tert-butyldiphenyl((18Z,21Z,24Z)-12-(phenylsulfonyl)triaconta-18,21,24-trienyloxy)silane
  参考文献：
  名称：

  Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids

  摘要：

  First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, 34:5n5, and three other unlabeled very long chain C30-32 containing polyunsaturated fatty acids are reported. These syntheses were achieved by coupling chemically modified C22- and C20-containing polyunsaturated fatty acids with carbanions derived from arylalkyl sulfones, followed by sodium amalgam-mediated desulfonylation. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.139

文献信息

• Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids
  作者：Ghulam M. Maharvi、Albert O. Edwards、Abdul H. Fauq

  DOI：10.1016/j.tetlet.2010.09.139

  日期：2010.12

  First syntheses of a deuterium-labeled very long C34-containing polyunsaturated fatty acid, 34:5n5, and three other unlabeled very long chain C30-32 containing polyunsaturated fatty acids are reported. These syntheses were achieved by coupling chemically modified C22- and C20-containing polyunsaturated fatty acids with carbanions derived from arylalkyl sulfones, followed by sodium amalgam-mediated desulfonylation. (C) 2010 Elsevier Ltd. All rights reserved.