methyl 4-(4-vinylbenzoyl)benzoate | 77832-40-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 4-(4-vinylbenzoyl)benzoate
• 英文别名: Methyl 4-(4-ethenylbenzoyl)benzoate；methyl 4-(4-ethenylbenzoyl)benzoate
• CAS: 77832-40-7
• 化学式: C₁₇H₁₄O₃
• 分子量: 266.296
• InChiKey: MTUBPJBWBVHOSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  异氰酸叔丁酯 、 4-碘苯甲酸甲酯 、 4-乙烯基苯硼酸 在 potassium phosphate 、 三苯基膦 、 palladium dichloride 、 盐酸 作用下， 以 甲苯 、 四氢呋喃 、 水 为溶剂， 反应 24.0h， 以64%的产率得到methyl 4-(4-vinylbenzoyl)benzoate
  参考文献：
  名称：

  Palladium-Catalyzed Synthesis of Biaryl Ketones via tert-Butyl Isocyanide Insertion

  摘要：

  A simple and efficient palladium-catalyzed carbonylative Suzuki coupling via tert-butyl isocyanide insertion has been developed, which demonstrates the utility of isocyanides in intermolecular C-C bond construction. This methodology provides a novel pathway for the synthesis of diaryl ketones in moderate to good yields. The approach is tolerant to a wide range of substrates and applicable to library synthesis. A possible reaction mechanism was proposed based on the experimental results.

  DOI：

  10.1055/s-0033-1341244

文献信息

• Palladium-Catalyzed Synthesis of Biaryl Ketones via tert-Butyl Isocyanide Insertion
  作者：Yongming Zhu、Zhong Chen、Huaqing Duan、Xiao Jiang、Jinmei Wang、Shilin Yang

  DOI：10.1055/s-0033-1341244

  日期：——

  A simple and efficient palladium-catalyzed carbonylative Suzuki coupling via tert-butyl isocyanide insertion has been developed, which demonstrates the utility of isocyanides in intermolecular C-C bond construction. This methodology provides a novel pathway for the synthesis of diaryl ketones in moderate to good yields. The approach is tolerant to a wide range of substrates and applicable to library synthesis. A possible reaction mechanism was proposed based on the experimental results.