COMPLEXES OF TRANSITION AND NONTRANSITION METALS OF DITHIOCARBAZATE ION AND THEIR BIOLOGICAL ACTIVITIES
作者:M. T.H. Tarafder、A. M Ali、Y. W. Wong、S. H. Wong、K. A. Crouse
DOI:10.1081/sim-100001937
日期:2001.3.29
The complexation of the dithiocarbazate ion (DTCA(-)) with various metal ions, viz., Sn(II)/(IV), Bi(III), Sb(III), U(VI), Zr(IV), Th(IV), AI(III), Ni(II), Zn(II), and Cu(II) was investigated. Most of the complexes were hexa-coordinated with the exception of Cu(II), Ni(II), and Zn(II) complexes that were four-coordinated, The biological properties of the metal complexes revealed that in general the complexes of nontransition metals were more effective against microorganisms than those of transition metals. In particular, [Sb(DTCA)Cl-2. 2H(2)O] and [AI(DTCA)Cl-2. 2H(2)O] were found to have strong antimicrobial activities. A minimum inhibitory concentration of 300 mug/mL was recorded for the above two complexes against Pseudomonas aeruginosa while that against Bacillus cereus was found to be 700 mug/mL. None of the complexes were cytotoxic.