6,7-dimethoxy-1'-phenylspiro[3,4-dihydro-2H-isoquinoline-1,3'-pyrrolidine]-2',5'-dione | 1426390-55-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 6,7-dimethoxy-1'-phenylspiro[3,4-dihydro-2H-isoquinoline-1,3'-pyrrolidine]-2',5'-dione
• CAS: 1426390-55-7
• 化学式: C₂₀H₂₀N₂O₄
• 分子量: 352.39
• InChiKey: GETNOGFQEXHVQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  tert-butyl (2-bromo-4,5-dimethoxyphenethyl)carbamate 在 四(三苯基膦)钯 、 正丁基锂 、 sodium carbonate 、 potassium carbonate 、 三氟乙酸 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 为溶剂， 反应 0.62h， 生成 6,7-dimethoxy-1'-phenylspiro[3,4-dihydro-2H-isoquinoline-1,3'-pyrrolidine]-2',5'-dione 、
  参考文献：
  名称：

  Study of aza-cyclization of α,β-unsaturated carbonyl moieties and synthetic application to hexahydroapoerysopine

  摘要：

  Aza-cyclization of alpha,beta-unsaturated carbonyl moieties with free amine has been studied. An azepine alkaloid, hexahydroapoerysopine, has been synthesized from an enone-ester in a concise manner through the aza-cyclization followed by reductions. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.01.093

文献信息

• Study of aza-cyclization of α,β-unsaturated carbonyl moieties and synthetic application to hexahydroapoerysopine
  作者：Hee Dong Kim、Guncheol Kim

  DOI：10.1016/j.tetlet.2013.01.093

  日期：2013.3

  Aza-cyclization of alpha,beta-unsaturated carbonyl moieties with free amine has been studied. An azepine alkaloid, hexahydroapoerysopine, has been synthesized from an enone-ester in a concise manner through the aza-cyclization followed by reductions. (C) 2013 Elsevier Ltd. All rights reserved.