1-(4-aminoquinazolin-7-ylmethyl)-4-(3-chloro-1-(toluene-4-sulfonyl)-1H-indol-6-ylmethyl)piperazin-2-one | 234108-81-7

• 分子结构分类: 有机化合物
• 英文名称: 1-(4-aminoquinazolin-7-ylmethyl)-4-(3-chloro-1-(toluene-4-sulfonyl)-1H-indol-6-ylmethyl)piperazin-2-one
• 英文别名: 1-[(4-Aminoquinazolin-7-yl)methyl]-4-[[3-chloro-1-(4-methylphenyl)sulfonylindol-6-yl]methyl]piperazin-2-one
• CAS: 234108-81-7
• 化学式: C₂₉H₂₇ClN₆O₃S
• 分子量: 575.091
• InChiKey: CTWUZGAKSMYGPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  123
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Substituted oxoazaheterocyclyl compounds
  申请人：AVENTIS PHARMACEUTICALS INC.

  公开号：US20040102450A1

  公开（公告）日：2004-05-27

  This invention is directed to oxoazaheterocycyl compounds which inhibit Factor Xa, to oxoazaheterocycyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa..

  这项发明涉及抑制因子Xa的氧杂杂环化合物，抑制同时抑制因子Xa和因子IIa的氧杂杂环化合物，包含这些化合物的药物组合物，用于制备这些化合物的中间体，直接抑制因子Xa的方法，以及同时直接抑制因子Xa和因子IIa的方法。
• SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS
  申请人：Aventis Pharmaceuticals Inc.

  公开号：EP1208097A2

  公开（公告）日：2002-05-29
• US7612075B2
  申请人：——

  公开号：US7612075B2

  公开（公告）日：2009-11-03
• [EN] SUBSTITUTED OXOAZAHETEROCYCLYL COMPOUNDS<br/>[FR] COMPOSES D'OXOAZAHETEROCYCLYLE SUBSTITUE
  申请人：AVENTIS PHARM PROD INC

  公开号：WO2001007436A2

  公开（公告）日：2001-02-01

  This invention is directed to oxoazaheterocyclyl compounds which inhibit Factor Xa, to oxoazaheterocyclyl compounds which inhibit both Factor Xa and Factor IIa, to pharmaceutical compositions comprising these compounds, to intermediates useful for preparing these compounds, to a method of directly inhibiting Factor Xa and to a method of simultaneously directly inhibiting Factor Xa and Factor IIa.