1,3-bis(4-chlorophenethyl)pyrimidine-2,4,6(1H,3H,5H)-trione | 1276033-00-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1,3-bis(4-chlorophenethyl)pyrimidine-2,4,6(1H,3H,5H)-trione
• 英文别名: 1,3-bis-(4-chlorophenethyl)pyrimidine-2,4,6-trione；1,3-bis[2-(4-chlorophenyl)ethyl]-1,3-diazinane-2,4,6-trione
• CAS: 1276033-00-1
• 化学式: C₂₀H₁₈Cl₂N₂O₃
• 分子量: 405.281
• InChiKey: SGTZNSXBHXPZQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  57.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PYRIMIDINE-2,4,6-TRIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS
  申请人：Cambria Pharmaceuticals, Inc.

  公开号：EP2427438B1

  公开（公告）日：2016-10-12
• SELECTIVE CALCIUM CHANNEL ANTAGONISTS
  申请人：Northwestern University

  公开号：US20160310491A1

  公开（公告）日：2016-10-27

  The present invention relates to compositions and methods for the treatment and/or prevention of neurodegenerative disorders, e.g., Parkinson's disease (PD). In particular, the present invention provides compositions comprising selective antagonists of calcium ion channels (e.g., cav1.3-type ion channels), and methods of use thereof to treat or prevent neurodegenerative disorders.
• US9499494B2
  申请人：——

  公开号：US9499494B2

  公开（公告）日：2016-11-22
• [EN] PYRIMIDINE-2,4,6-TRIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS<br/>[FR] PYRIMIDINE-2,4,6-TRIONES DESTINÉE À ÊTRE UTILISÉE POUR LE TRAITEMENT D'UNE SCLÉROSE LATÉRALE AMYOTROPHE
  申请人：CAMBRIA PHARMACEUTICALS INC

  公开号：WO2010129665A2

  公开（公告）日：2010-11-11

  The present invention relates to the identification of inventive pyrimidine-2,4,6- triones (PYT compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the inventive PYT compounds.