2-[[4-(cyclopentyloxy)phenyl]methyl]-N,N-diethyl-1-(3-methaneylbutyl)-1H-benzoimidazole-5-carboxamide | 1046140-53-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[[4-(cyclopentyloxy)phenyl]methyl]-N,N-diethyl-1-(3-methaneylbutyl)-1H-benzoimidazole-5-carboxamide
• 英文别名: 2-[[4-(cyclopentyloxy)phenyl]methyl]-N,N-diethyl-1-(3-methylbutyl)-1H-benzoimidazole-5-carboxamide；2-[[4-(cyclopentyloxy)phenyl]methyl]-N,N-diethyl-1-(3-methylbutyl)-1H-benzimidazole-5-carboxamide；2-(4-(cyclopentyloxy)benzyl)-N,N-diethyl-1-isopentyl-1H-benzo[d]imidazole-5-carboxamide；2-[(4-cyclopentyloxyphenyl)methyl]-N,N-diethyl-1-(3-methylbutyl)benzimidazole-5-carboxamide
• CAS: 1046140-53-7
• 化学式: C₂₉H₃₉N₃O₂
• 分子量: 461.648
• InChiKey: NILJSCAJHVULQP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  47.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  反应 2.0h， 生成 2-[[4-(cyclopentyloxy)phenyl]methyl]-N,N-diethyl-1-(3-methaneylbutyl)-1H-benzoimidazole-5-carboxamide
  参考文献：
  名称：

  Novel benzimidazole derivatives as selective CB2 agonists

  摘要：

  The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1 nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to excellent selectivity (> 1000-fold) over the CB1 receptor. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.073

文献信息

• Novel compounds
  申请人：Cheng Yun-Xing

  公开号：US20060135554A1

  公开（公告）日：2006-06-22

  Compounds of general formula I are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain.

  本申请披露和声明了一般式I的化合物，以及包括这些新化合物的盐和药物组合物，并且这些化合物在治疗中的使用，特别是在疼痛管理方面。
• US7030139B2
  申请人：——

  公开号：US7030139B2

  公开（公告）日：2006-04-18