[4-anilino-2,6-bis(4-fluorophenyl)-1-phenyl-3,6-dihydro-2H-pyridin-5-yl]-phenylmethanone | 1603825-16-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-anilino-2,6-bis(4-fluorophenyl)-1-phenyl-3,6-dihydro-2H-pyridin-5-yl]-phenylmethanone
• CAS: 1603825-16-6
• 化学式: C₃₆H₂₈F₂N₂O
• 分子量: 542.628
• InChiKey: PLCXSPVUVAAKTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9
• 重原子数：
  41
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  对氟苯甲醛 、 苯胺 、 1-苯基-1,3-丁二酮 在 polyphosphoric acid clay pillared with zirconia polycation 作用下， 以 乙腈 为溶剂， 以72.6%的产率得到[4-anilino-2,6-bis(4-fluorophenyl)-1-phenyl-3,6-dihydro-2H-pyridin-5-yl]-phenylmethanone
  参考文献：
  名称：

  Polyphosphoric acid–zirconia pillared clay composite catalytic system for efficient multicomponent one pot synthesis of tetrahydropyridines under environmentally benign conditions

  摘要：

  A series of zirconia pillared clay-polyphosphoric acid (PPA) composites are synthesized by adopting different preparative strategies. Initially, PPA is intercalated to the clay matrix with and without the use of structure expanding agent (CTAB). Subsequently, the PPA-clay composite is pillared with Zrpolycation to form the composite materials. In an alternate approach, Zr-pillared clay is synthesized by insertion of Zr-polycation, which is then used for dispersion of PPA moiety in the pillared clay matrix. The synthesized composites are characterized by XRD, FTIR, UV-vis, TGA, EDX, FE-SEM and sorptometric techniques. XRD study indicated an expansion in the clay structure after intercalation of PPA as well as the Zr-polycations. The FTIR spectra exhibit characteristic vibrational features of the clay sheet as well as PPA moiety indicating the structural stability of the composite materials. The phosphorous content in the composite samples is analyzed using EDX study. FE-SEM study indicated morphological changes upon intercalation of PPA and Zr-polycations to the clay matrix. The catalytic activity of the composite catalysts has been examined for the synthesis of tetrahydropyridines under environmental benign conditions by one pot multicomponent condensation of beta-dicarbonyl compounds, substituted anilines and substituted benzaldehydes. The PPA intercalated clay pillared with Zr polycations (PPA-ZrP) is found to be highly efficient for the synthesis of structurally diverse substituted tetrahydropyridines under mild conditions. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2014.02.024

文献信息

• Polyphosphoric acid–zirconia pillared clay composite catalytic system for efficient multicomponent one pot synthesis of tetrahydropyridines under environmentally benign conditions
  作者：Purabi Kar、B.G. Mishra、S.R. Pradhan

  DOI：10.1016/j.molcata.2014.02.024

  日期：2014.6

  A series of zirconia pillared clay-polyphosphoric acid (PPA) composites are synthesized by adopting different preparative strategies. Initially, PPA is intercalated to the clay matrix with and without the use of structure expanding agent (CTAB). Subsequently, the PPA-clay composite is pillared with Zrpolycation to form the composite materials. In an alternate approach, Zr-pillared clay is synthesized by insertion of Zr-polycation, which is then used for dispersion of PPA moiety in the pillared clay matrix. The synthesized composites are characterized by XRD, FTIR, UV-vis, TGA, EDX, FE-SEM and sorptometric techniques. XRD study indicated an expansion in the clay structure after intercalation of PPA as well as the Zr-polycations. The FTIR spectra exhibit characteristic vibrational features of the clay sheet as well as PPA moiety indicating the structural stability of the composite materials. The phosphorous content in the composite samples is analyzed using EDX study. FE-SEM study indicated morphological changes upon intercalation of PPA and Zr-polycations to the clay matrix. The catalytic activity of the composite catalysts has been examined for the synthesis of tetrahydropyridines under environmental benign conditions by one pot multicomponent condensation of beta-dicarbonyl compounds, substituted anilines and substituted benzaldehydes. The PPA intercalated clay pillared with Zr polycations (PPA-ZrP) is found to be highly efficient for the synthesis of structurally diverse substituted tetrahydropyridines under mild conditions. (C) 2014 Elsevier B.V. All rights reserved.