(2E,2′E)-5,5′-(1,3-Phenylene)bis(1-phenylpent-2-en-4-yn-1-one) | 1514900-45-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2E,2′E)-5,5′-(1,3-Phenylene)bis(1-phenylpent-2-en-4-yn-1-one)
• CAS: 1514900-45-8
• 化学式: C₂₈H₁₈O₂
• 分子量: 386.45
• InChiKey: RKNHHBFEENJWFI-VDEHPEQNSA-N

反应信息

• 作为反应物：
  描述：

  (2E,2′E)-5,5′-(1,3-Phenylene)bis(1-phenylpent-2-en-4-yn-1-one) 、 5,5-二甲基-1,3-环己二酮 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 乙腈 为溶剂， 反应 20.0h， 以89%的产率得到2,2'-(1,3-phenylenebis(methylene))bis(6,6-dimethyl-3-(2-oxo-2-phenylethyl)-6,7-dihydrobenzofuran-4(5H)-one)
  参考文献：
  名称：

  A Metal-Free Tandem C–C/C–O Bond Formation Approach to Diversely Functionalized Tetrasubstituted Furans

  摘要：

  A novel and efficient method for the synthesis of diversely functionalized furans is developed via DBU-mediated tandem Michael addition/5-exo-dig-cycloisomerization of enynes and keto-methylenes. This [3 + 2]-annulation is operationally simple under metal-free reaction conditions with 100% atom economy and broad substrate scope.

  DOI：

  10.1021/jo4023342
• 作为产物：
  描述：

  3-[3-(3-oxoprop-1-ynyl)phenyl]prop-2-ynal 、 alkaline earth salt of/the/ methylsulfuric acid 以69%的产率得到(2E,2′E)-5,5′-(1,3-Phenylene)bis(1-phenylpent-2-en-4-yn-1-one)
  参考文献：
  名称：

  A Metal-Free Tandem C–C/C–O Bond Formation Approach to Diversely Functionalized Tetrasubstituted Furans

  摘要：

  A novel and efficient method for the synthesis of diversely functionalized furans is developed via DBU-mediated tandem Michael addition/5-exo-dig-cycloisomerization of enynes and keto-methylenes. This [3 + 2]-annulation is operationally simple under metal-free reaction conditions with 100% atom economy and broad substrate scope.

  DOI：

  10.1021/jo4023342