2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid benzylamide | 65906-67-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid benzylamide
• 英文别名: N-Benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide；N-benzyl-2,4-dioxo-1H-pyrimidine-5-carboxamide
• CAS: 65906-67-4
• 化学式: C₁₂H₁₁N₃O₃
• mdl: MFCD26404026
• 分子量: 245.238
• InChiKey: NUCVHPZNCBEPER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  87.3
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• NUCLEOSIDE DERIVATIVE OR SALT THEREOF, POLYNUCLEOTIDE SYNTHESIS REAGENT, METHOD FOR PRODUCING POLYNUCLEOTIDE, POLYNUCLEOTIDE, AND METHOD FOR PRODUCING BINDING NUCLEIC ACID MOLECULE
  申请人：NEC Solution Innovators, Ltd.

  公开号：US20190248826A1

  公开（公告）日：2019-08-15

  The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L 1 and L 2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X 1 and X 2 are each independently an imino group (—NR 1 —), an ether group (—O—), or a thioether group (—S—), and the R 1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.

  本发明提供了一种新颖的核苷酸衍生物或其盐，一种聚核苷酸合成试剂，一种制备聚核苷酸的方法，一种聚核苷酸，以及一种制备结合核酸分子的方法。本发明的核苷酸衍生物或其盐由以下化学式（1）表示：在化学式（1）中，Su是具有核苷酸残基上的糖骨架或具有核苷酸残基上的糖磷酸骨架的原子团，可能有或没有保护基，L1和L2分别是独立的直链或支链、饱和或不饱和的碳原子数为2到10的烃基，X1和X2分别是独立的亚胺基（—NR1—）、醚基（—O—）或硫醚基（—S—），R1是氢原子或独立的直链或支链、饱和或不饱和的碳原子数为2到10的烃基。
• PEANUT-BINDING NUCLEIC ACID MOLECULE AND USE THEREOF
  申请人：NEC Solution Innovators, Ltd.

  公开号：EP3078747A1

  公开（公告）日：2016-10-12

  The present invention provides a novel nucleic acid molecule that can be used for detection of peanuts. The peanut-binding nucleic acid molecule of the present invention is characterized in that it binds to a peanut allergen with a dissociation constant of 10 nM or less, and preferably contains a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 15, for example. It is also preferable that, for example, the peanut-binding nucleic acid molecule of the present invention binds with significant specificity to the peanut allergen rather than to a soybean protein.

  本发明提供了一种可用于检测花生的新型核酸分子。本发明的花生结合型核酸分子的特征在于，它与花生过敏原的结合解离常数为 10 nM 或更低，并且优选包含由 SEQ ID NOs: 1 至 15 的任意碱基序列组成的多核苷酸。例如，本发明的花生结合核酸分子最好还能与花生过敏原而不是大豆蛋白结合，并具有显著的特异性。
• WHEAT ALLERGEN-BINDING NUCLEIC ACID MOLECULE AND USE THEREOF
  申请人：NEC Solution Innovators, Ltd.

  公开号：EP3378939A1

  公开（公告）日：2018-09-26

  The present invention provides a novel nucleic acid molecule that can be used for detection of a wheat allergen. The wheat allergen-binding nucleic acid according to the present invention is characterized in that it binds to a wheat allergen with a dissociation constant of 20 nM or less, and preferably includes a polynucleotide consisting of either of base sequences of SEQ ID NOs: 1 and 2, for example.

  本发明提供了一种可用于检测小麦过敏原的新型核酸分子。根据本发明的小麦过敏原结合核酸，其特征在于它能以 20 nM 或更小的解离常数与小麦过敏原结合，并且优选包括由 SEQ ID NOs: 1 和 2 的碱基序列（例如）中任一碱基序列组成的多核苷酸。
• TARGET ANALYSIS METHOD AND TARGET ANALYSIS KIT FOR USE IN SAID METHOD
  申请人：NEC Solution Innovators, Ltd.

  公开号：EP3406735A1

  公开（公告）日：2018-11-28

  The present invention provides a new target analysis method and a target analysis kit for use in the method. The target analysis method of the present invention includes: causing a specimen, a labeled binding nucleic acid molecule that binds to a target, and a carrier on which a blocking nucleic acid molecule that binds to the labeled binding nucleic acid molecule is immobilized to react; separating a fraction of the carrier and a fraction of components other than the carrier from each other; and detecting a label of the labeled binding nucleic acid molecule in at least one of the fraction of the carrier and the fraction of components other than the carrier to analyze a target in the specimen.

  本发明提供了一种新的目标分析方法和用于该方法的目标分析试剂盒。本发明的靶标分析方法包括使试样、与靶标结合的标记结合核酸分子和载体发生反应，在载体上固定与标记结合核酸分子结合的阻断核酸分子；将载体的一部分和载体以外的部分相互分离；检测载体的一部分和载体以外的部分中至少一个部分中标记结合核酸分子的标签，以分析试样中的靶标。
• Nucleoside derivative or salt thereof, polynucleotide synthesis reagent, method for producing polynucleotide, polynucleotide, and method for producing binding nucleic acid molecule
  申请人：NEC Solution Innovators, Ltd.

  公开号：US10611791B2

  公开（公告）日：2020-04-07

  The present invention provides a novel nucleoside derivative or a salt thereof, a polynucleotide synthesis reagent, a method for producing a polynucleotide, a polynucleotide, and a method for producing a binding nucleic acid molecule. The nucleoside derivative or a salt thereof of the present invention is represented by the following chemical formula (1): where in the chemical formula (1), Su is an atomic group having a sugar skeleton at a nucleoside residue or an atomic group having a sugar phosphate skeleton at a nucleotide residue, and may or may not have a protecting group, L1 and L2 are each independently a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms, X1 and X2 are each independently an imino group (—NR1—), an ether group (—O—), or a thioether group (—S—), and the R1 is a hydrogen atom or a straight-chain or branched, saturated or unsaturated hydrocarbon group having 2 to 10 carbon atoms.

  本发明提供了一种新型核苷衍生物或其盐，一种多核苷酸合成试剂，一种生产多核苷酸的方法，一种多核苷酸，以及一种生产结合核酸分子的方法。 本发明的核苷衍生物或其盐由以下化学式（1）表示： 其中在化学式（1）中，Su 是在核苷残基上具有糖骨架的原子团，或在核苷酸残基上具有糖磷酸骨架的原子团，可以有或没有保护基，L1 和 L2 各自独立地是直链或支链、X1和X2各自独立地为亚氨基（-NR1-）、醚基（-O-）或硫醚基（-S-），R1为氢原子或具有2至10个碳原子的直链或支链、饱和或不饱和烃基。