carbamic acid 3-[4-(3,5-di-tert-butyl-benzylamino)-phenyl]-isoxazol-5-ylmethyl ester | 1242297-46-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: carbamic acid 3-[4-(3,5-di-tert-butyl-benzylamino)-phenyl]-isoxazol-5-ylmethyl ester
• 英文别名: [3-[4-[(3,5-Ditert-butylphenyl)methylamino]phenyl]-1,2-oxazol-5-yl]methyl carbamate
• CAS: 1242297-46-6
• 化学式: C₂₆H₃₃N₃O₃
• 分子量: 435.566
• InChiKey: OUUMGGLFVRBTMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  90.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME
  申请人：Park Cheol-Hyoung

  公开号：US20110301150A1

  公开（公告）日：2011-12-08

  Provided are a substituted azole derivative and pharmaceutically acceptable salts thereof, a pharmaceutical composition including an effective amount of the derivative, and a method for treating Parkinson's disease in a mammal including administering an effective amount of the compound to the mammal. The azole derivative of the following Formula (I) and pharmaceutically useful salts thereof have an efficacy against Parkinson's disease from inhibitory effects of the activity of MAO-B.

  提供了一种替代的唑类衍生物及其药学上可接受的盐，一种包括有效量衍生物的制药组合物，以及一种治疗哺乳动物帕金森病的方法，包括向哺乳动物施用化合物的有效量。以下公式（I）的唑类衍生物及其药学上有用的盐具有抗帕金森病的功效，来自于对MAO-B活性的抑制作用。
• US8828992B2
  申请人：——

  公开号：US8828992B2

  公开（公告）日：2014-09-09
• [EN] SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME<br/>[FR] DÉRIVÉS D'AZOLE SUBSTITUÉS, COMPOSITION PHARMACEUTIQUE CONTENANT LES DÉRIVÉS ET PROCÉDÉ DE TRAITEMENT DE LA MALADIE DE PARKINSON À L'AIDE DE CEUX-CI
  申请人：SK HOLDINGS CO LTD

  公开号：WO2010098600A2

  公开（公告）日：2010-09-02

  Provided are a substituted azole derivative and pharmaceutically acceptable salts thereof, a pharmaceutical composition including an effective amount of the derivative, and a method for treating Parkinson's disease in a mammal including administering an effective amount of the compound to the mammal. The azole derivative of the following Formula (I) and pharmaceutically useful salts thereof have an efficacy against Parkinson's disease from inhibitory effects of the activity of MAO-B.