2-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-6-phenylpyrimidin-4(3H)-one | 1449772-53-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-6-phenylpyrimidin-4(3H)-one
• CAS: 1449772-53-5
• 化学式: C₂₃H₂₆N₄O₄S
• 分子量: 454.55
• InChiKey: BNGWJBFQDZUAHC-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-6-phenylpyrimidin-4(3H)-one 在 吡啶 、 溴 作用下， 以 二氯甲烷 为溶剂， 反应 0.17h， 以68%的产率得到5-bromo-2-(2-ethoxy-5-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-6-phenylpyrimidin-4(3H)-one
  参考文献：
  名称：

  Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5

  摘要：

  The substituents both at the 6-position of the 5-bromopyrimidinone ring and at the 5'-position of the phenyl ring of 5-bromopyrimidin-4(3H)-ones were explored. 5-Bromo-6-isopropyl-2-(2-propoxyphenyl)pyrimidin-4(3H)-one was identified as a new scaffold for potent PDE5 inhibitors. The crystal structures of PDE5/2e and PDE5/10a complexes provided a structural basis for the inhibition of 5-bromopyrimidinones to PDE5. In addition, it was also found that there is a great tolerance for the substitution at the 5'-position of the phenyl ring of 5-bormopyrimidinones and the resulted compound 13a has the highest inhibition activity to PDE5 (IC50, 1.7 nM). (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.06.062