1-[(2R,3R,4R,5R)-3-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]pyrimidine-2,4-dione | 1134031-72-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-[(2R,3R,4R,5R)-3-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]pyrimidine-2,4-dione
• CAS: 1134031-72-3
• 化学式: C₁₆H₂₈N₂O₆Si
• 分子量: 372.494
• InChiKey: AKIZFCWTPQDTFU-FMKGYKFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.83
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  97.3
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-[(2R,3R,4R,5R)-3-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]pyrimidine-2,4-dione 、 (2S,3S,4S,5S,6S)-2-(((2,6-dichloro-4-methoxyphenyl)(2,4-dichlorophenyl)methoxy)carbonyl)-6-(2,2,2-trichloro-1-iminoethoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthetic Studies towards the Identification of Novel Capuramycin Analogs with Mycobactericidal Activity

  摘要：

  Expeditious syntheses of capuramycin, an effective MraY inhibitor in vivo, analogs are described. Synthetic schemes reported here are extremely useful for the generation of capuramycin analogs to identify minimum structure requirement to exhibit antimycobactericidal activity.

  DOI：

  10.3987/com-08-s(f)38
• 作为产物：
  描述：

  在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 以100%的产率得到1-[(2R,3R,4R,5R)-3-[tert-butyl(dimethyl)silyl]oxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]pyrimidine-2,4-dione
  参考文献：
  名称：

  Synthetic Studies towards the Identification of Novel Capuramycin Analogs with Mycobactericidal Activity

  摘要：

  Expeditious syntheses of capuramycin, an effective MraY inhibitor in vivo, analogs are described. Synthetic schemes reported here are extremely useful for the generation of capuramycin analogs to identify minimum structure requirement to exhibit antimycobactericidal activity.

  DOI：

  10.3987/com-08-s(f)38

文献信息

• Synthetic Studies towards the Identification of Novel Capuramycin Analogs with Mycobactericidal Activity
  作者：Michio Kurosu、Kai Li

  DOI：10.3987/com-08-s(f)38

  日期：——

  Expeditious syntheses of capuramycin, an effective MraY inhibitor in vivo, analogs are described. Synthetic schemes reported here are extremely useful for the generation of capuramycin analogs to identify minimum structure requirement to exhibit antimycobactericidal activity.