4-amino-6-tert-butyl-pyrimidine-5-carbonitrile | 54122-62-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-amino-6-tert-butyl-pyrimidine-5-carbonitrile
• 英文别名: 4-Amino-6-tert-butylpyrimidine-5-carbonitrile
• CAS: 54122-62-2
• 化学式: C₉H₁₂N₄
• 分子量: 176.221
• InChiKey: YREIQCDGCAEJHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  75.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• CHEMICAL COMPOUNDS, COMPOSITIONS AND METHODS FOR KINASE MODULATION
  申请人：Ren Pingda

  公开号：US20120059000A1

  公开（公告）日：2012-03-08

  Chemical compounds that modulate kinase activity, including PI3 kinase activity, and chemical compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein.

  本文描述了调节激酶活性的化合物，包括PI3激酶活性的化合物，以及与激酶活性相关的疾病和病状的化合物、药物组合物和治疗方法。
• PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：US20150361071A1

  公开（公告）日：2015-12-17

  The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein n, m, R 1 , R 2 , R 3 , R 4 , and R 5 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.
• US9181221B2
  申请人：——

  公开号：US9181221B2

  公开（公告）日：2015-11-10
• US9499523B2
  申请人：——

  公开号：US9499523B2

  公开（公告）日：2016-11-22
• US9738644B2
  申请人：——

  公开号：US9738644B2

  公开（公告）日：2017-08-22