N-[3-[3-(tert-butylsulfinylamino)oxetan-3-yl]phenyl]acetamide | 1313872-45-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3-[3-(tert-butylsulfinylamino)oxetan-3-yl]phenyl]acetamide
• CAS: 1313872-45-5
• 化学式: C₁₅H₂₂N₂O₃S
• 分子量: 310.417
• InChiKey: MIUVIEPQJCHMOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  86.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3-[(叔丁基亚磺酰基)亚氨基]氧杂环丁烷 、 3-acetamidophenylboroxine 在 chloro(1,5-cyclooctadiene)rhodium(I) dimer 、 1,2-双(二苯基膦基)苯 、 sodium ethanolate 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 以88%的产率得到N-[3-[3-(tert-butylsulfinylamino)oxetan-3-yl]phenyl]acetamide
  参考文献：
  名称：

  Highly Functional Group Compatible Rh-Catalyzed Addition of Arylboroxines to Activated N-tert-Butanesulfinyl Ketimines

  摘要：

  The rhodium-catalyzed addition of readily accessible arylboroxines to N-tert-butanesulfinyl ketimines derived from oxetan-3-one, N-Boc-azetidin-3-one, and isatins proceeds In high yields with excellent functional group compatibility. Moreover, high diastereoselectivities are observed for the additions to the N-sulfinyl ketimines derived from isatins.

  DOI：

  10.1021/ol201438k

文献信息

• Highly Functional Group Compatible Rh-Catalyzed Addition of Arylboroxines to Activated <i>N</i>-<i>tert</i>-Butanesulfinyl Ketimines
  作者：Hyung Hoon Jung、Andrew W. Buesking、Jonathan A. Ellman

  DOI：10.1021/ol201438k

  日期：2011.8.5

  The rhodium-catalyzed addition of readily accessible arylboroxines to N-tert-butanesulfinyl ketimines derived from oxetan-3-one, N-Boc-azetidin-3-one, and isatins proceeds In high yields with excellent functional group compatibility. Moreover, high diastereoselectivities are observed for the additions to the N-sulfinyl ketimines derived from isatins.