7-(tert-butyldimethylsilyloxy)-2,2-dimethyl-2-silatetralin | 164591-63-3

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: 7-(tert-butyldimethylsilyloxy)-2,2-dimethyl-2-silatetralin
• 英文别名: tert-butyl-[(2,2-dimethyl-3,4-dihydro-1H-2-benzosilin-7-yl)oxy]-dimethylsilane
• CAS: 164591-63-3
• 化学式: C₁₇H₃₀OSi₂
• 分子量: 306.596
• InChiKey: RCYLUVJXEBEYHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.42
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  氯化苄 、 7-(tert-butyldimethylsilyloxy)-2,2-dimethyl-2-silatetralin 在 六甲基磷酰三胺 、 仲丁基锂 作用下， 生成 1-benzyl-7-(tert-butyldimethylsilyloxy)-2,2-dimethyl-2-silatetralin
  参考文献：
  名称：

  Reaction of 2-Silateralins with Alkyl Halides and Ketones under Basic Conditions

  摘要：

  The reaction of 2-silatetralins with alkyl halides (methyl iodide, benzyl chloride) and ketones (acetone, cyclohexanone) in sec-butyllithium (BuLi)-, sec-BuLi-tetramethylenediamine- or sec-BuLi-hexamethylphosphoramide-tetrahydrofuran media at lower temperature is described. The reaction gave rise to 1-alkylated 2-silatetralins in fair to good yield, serving a method for synthesis of a potent intermediate leading to novel silicon-containing compounds.

  DOI：

  10.3987/com-94-s98
• 作为产物：
  描述：

  叔丁基二甲基氯硅烷 、 7-hydroxy-2,2-dimethyl-2-silatetralin 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以69%的产率得到7-(tert-butyldimethylsilyloxy)-2,2-dimethyl-2-silatetralin
  参考文献：
  名称：

  Reaction of 2-Silateralins with Alkyl Halides and Ketones under Basic Conditions

  摘要：

  The reaction of 2-silatetralins with alkyl halides (methyl iodide, benzyl chloride) and ketones (acetone, cyclohexanone) in sec-butyllithium (BuLi)-, sec-BuLi-tetramethylenediamine- or sec-BuLi-hexamethylphosphoramide-tetrahydrofuran media at lower temperature is described. The reaction gave rise to 1-alkylated 2-silatetralins in fair to good yield, serving a method for synthesis of a potent intermediate leading to novel silicon-containing compounds.

  DOI：

  10.3987/com-94-s98

文献信息

• Reaction of 2-Silateralins with Alkyl Halides and Ketones under Basic Conditions
  作者：Osamu Hoshino、Toru Taguchi、Kenji Miyauchi、Atsuhiro Tatsuno

  DOI：10.3987/com-94-s98

  日期：——

  The reaction of 2-silatetralins with alkyl halides (methyl iodide, benzyl chloride) and ketones (acetone, cyclohexanone) in sec-butyllithium (BuLi)-, sec-BuLi-tetramethylenediamine- or sec-BuLi-hexamethylphosphoramide-tetrahydrofuran media at lower temperature is described. The reaction gave rise to 1-alkylated 2-silatetralins in fair to good yield, serving a method for synthesis of a potent intermediate leading to novel silicon-containing compounds.