4-(2-(2-chlorophenyl)-2-(4-chlorophenyl)vinylidene)-2,2,3,3,5-pentamethyl-3,4-dihydro-2H-pyrrole | 1028333-74-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-(2-chlorophenyl)-2-(4-chlorophenyl)vinylidene)-2,2,3,3,5-pentamethyl-3,4-dihydro-2H-pyrrole
• CAS: 1028333-74-5
• 化学式: C₂₃H₂₃Cl₂N
• 分子量: 384.348
• InChiKey: PIEMSUCUDMPIAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-chloro-4-(1-(2-chlorophenyl)-2-(2,2,3,3-tetramethylcyclopropylidene)vinyl)benzene 、 乙腈 在 三氟甲磺酸 作用下， 反应 0.17h， 以53%的产率得到N-(6-(2-chlorophenyl)-6-(4-chlorophenyl)-2,3,3-trimethylhex-4-yn-2-yl)acetamide
  参考文献：
  名称：

  Brønsted Acid TfOH-Mediated [3 + 2] Cycloaddition Reactions of Diarylvinylidenecyclopropanes with Nitriles

  摘要：

  Diarylvinylidenecyclopropanes undergo a [3 + 2] cycloaddition reaction with MeCN in the presence of Bronsted acid TfOH to give the corresponding 3,4-dihydro-2H-pyn-ole derivatives 2 in moderate to excellent yields under reflux within a short time. As for the diarylvinylidenecyclopropane substrate containing a strongly electron-donating methoxy group on the benzene ring, the reaction leads to the formation of a different type of 3,4-dihydro-2H-pyrrole derivatives 4 under the same conditions.

  DOI：

  10.1021/jo800390c

文献信息

• Brønsted Acid TfOH-Mediated [3 + 2] Cycloaddition Reactions of Diarylvinylidenecyclopropanes with Nitriles
  作者：Wei Li、Min Shi

  DOI：10.1021/jo800390c

  日期：2008.6.1

  Diarylvinylidenecyclopropanes undergo a [3 + 2] cycloaddition reaction with MeCN in the presence of Bronsted acid TfOH to give the corresponding 3,4-dihydro-2H-pyn-ole derivatives 2 in moderate to excellent yields under reflux within a short time. As for the diarylvinylidenecyclopropane substrate containing a strongly electron-donating methoxy group on the benzene ring, the reaction leads to the formation of a different type of 3,4-dihydro-2H-pyrrole derivatives 4 under the same conditions.