5,6,11,13-Tetramethyl-8-thia-3,10-diazatricyclo[7.4.0.02,7]trideca-1(9),2(7),5,10,12-pentaen-4-one | 1038743-86-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: 5,6,11,13-Tetramethyl-8-thia-3,10-diazatricyclo[7.4.0.02,7]trideca-1(9),2(7),5,10,12-pentaen-4-one
• 英文别名: 5,6,11,13-tetramethyl-8-thia-3,10-diazatricyclo[7.4.0.02,7]trideca-1(9),2(7),5,10,12-pentaen-4-one
• CAS: 1038743-86-0
• 化学式: C₁₄H₁₄N₂OS
• 分子量: 258.344
• InChiKey: LWUUFFKWWDXABS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  diethyl (1-((2-acetyl-4,6-dimethylthieno[2,3-b]pyridin-3-yl)amino)-1-oxopropan-2-yl)phosphonate 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 lithium chloride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以100%的产率得到5,6,11,13-Tetramethyl-8-thia-3,10-diazatricyclo[7.4.0.02,7]trideca-1(9),2(7),5,10,12-pentaen-4-one
  参考文献：
  名称：

  A facile Horner–Wadsworth–Emmons route to 2-quinolones

  摘要：

  2-Quinolones are prepared from o-aminophenylketones by N-acylation with phosphonoalkanoylchlorides, followed by an intramolecular Horner-Wadsworth-Emmons olefination. The transformation proceeds under mild conditions, is generally applicable, gives good yields and can be performed either in two steps or as a one-pot reaction. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.04.088

文献信息

• A facile Horner–Wadsworth–Emmons route to 2-quinolones
  作者：Jens-Uwe Peters、Tony Capuano、Silja Weber、Stéphane Kritter、Matthias Sägesser

  DOI：10.1016/j.tetlet.2008.04.088

  日期：2008.6

  2-Quinolones are prepared from o-aminophenylketones by N-acylation with phosphonoalkanoylchlorides, followed by an intramolecular Horner-Wadsworth-Emmons olefination. The transformation proceeds under mild conditions, is generally applicable, gives good yields and can be performed either in two steps or as a one-pot reaction. (C) 2008 Elsevier Ltd. All rights reserved.