2-Amino-4-ethyl-5-oxo-4,6-dihydropyrano[3,2-c]quinoline-3-carbonitrile | 1309378-47-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 2-Amino-4-ethyl-5-oxo-4,6-dihydropyrano[3,2-c]quinoline-3-carbonitrile
• 英文别名: 2-amino-4-ethyl-5-oxo-4,6-dihydropyrano[3,2-c]quinoline-3-carbonitrile
• CAS: 1309378-47-9
• 化学式: C₁₅H₁₃N₃O₂
• 分子量: 267.287
• InChiKey: WRNGBMBALMRANX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  88.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4-喹啉二醇 、 丙醛 、 丙二腈 在 ammonium acetate 作用下， 以 乙醇 为溶剂， 反应 0.33h， 以80%的产率得到2-Amino-4-ethyl-5-oxo-4,6-dihydropyrano[3,2-c]quinoline-3-carbonitrile
  参考文献：
  名称：

  A green, efficient, and rapid procedure for the synthesis of 2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-one derivatives catalyzed by ammonium acetate

  摘要：

  A green, efficient, and rapid procedure for the synthesis of 2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-one derivatives has been developed by one-pot condensation of 4-hydroxyquinolin-2(1H)-one, aldehyde, and malononitrile in the presence of ammonium acetate in EtOH. This method has the advantages of operational simplicity, mild reaction conditions, short reaction time, and little environmental impact. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.03.061

文献信息

• A green, efficient, and rapid procedure for the synthesis of 2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-one derivatives catalyzed by ammonium acetate
  作者：Min Lei、Lei Ma、Lihong Hu

  DOI：10.1016/j.tetlet.2011.03.061

  日期：2011.5

  A green, efficient, and rapid procedure for the synthesis of 2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-one derivatives has been developed by one-pot condensation of 4-hydroxyquinolin-2(1H)-one, aldehyde, and malononitrile in the presence of ammonium acetate in EtOH. This method has the advantages of operational simplicity, mild reaction conditions, short reaction time, and little environmental impact. (C) 2011 Elsevier Ltd. All rights reserved.