Ph3PAu[SC(OiPr)NC6H5] | 149160-53-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ph3PAu[SC(OiPr)NC6H5]
• 英文别名: {triphenylphosphinegold(I)-SC(=NPh)O(i-Pr)}；Ph₃PAu[SC(OiPr)NC₆H₅]
• CAS: 149160-53-2
• 化学式: C₂₈H₂₇AuNOPS
• 分子量: 653.535
• InChiKey: JSLFBYZGYVMDQK-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  6.74
• 重原子数：
  33.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  21.59
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  三苯基膦 在 sodium hydroxide 、 sodium sulfite 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 Ph3PAu[SC(OiPr)NC6H5]
  参考文献：
  名称：

  The influence of R substituents in triphenylphosphinegold(I) carbonimidothioates, Ph3PAu[SC(OR)=NPh] (R=Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways

  摘要：

  The Ph3PAu[SC(OR) = NPh], R = Me (1), Et (2) and iPr (3), compounds are significantly cytotoxic to the HT-29 cancer cell line with 1 being the most active. Based on human apoptosis PCR-array analysis, caspase activities, DNA fragmentation, cell apoptotic assays, intracellular reactive oxygen species (ROS) measurements and human topoisomerase I inhibition, induction of apoptosis is demonstrated and both the extrinsic and intrinsic pathways of apoptosis have been shown to occur. Compound 1 activates the p73 gene, whereas each of 2 and 3 activates the p53 gene. An additional apoptotic mechanism is exhibited by 2, that is, via the JNK/MAP pathway. (c) 2013 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jinorgbio.2013.05.011

文献信息

• Hall, Veronica J.; Siasios, George; Tiekink, Edward R. T., Australian Journal of Chemistry, 1993, vol. 46, # 4, p. 561 - 570
  作者：Hall, Veronica J.、Siasios, George、Tiekink, Edward R. T.

  DOI：——

  日期：——