2,4-Dichlor-3,5-diethylphenol | 38730-38-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-Dichlor-3,5-diethylphenol
• 英文别名: 2,4-dichloro-3,5-diethylphenol
• CAS: 38730-38-0
• 化学式: C₁₀H₁₂Cl₂O
• 分子量: 219.111
• InChiKey: FSMQFPSXJKGYOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• MEDICAL ADHESIVE COMPOSITIONS
  申请人：Liu Hongbo

  公开号：US20110230561A1

  公开（公告）日：2011-09-22

  A medical adhesive composition comprising, based upon the total weight of the composition, from about 50 wt. % to about 99.9 wt. % of one or more α-cyanoacrylate monomers and from about 0.1 wt. % to about 5 wt. % of one or more non-steroidal anti-inflammatory drugs (NSAIDs). Suitable NSAIDs include ibuprofen and acetaminophen. The resulting compositions provide enhances fibroblast proliferation and reduced cytotoxicity compared to compositions that do not contain NSAID.

  一种医用粘合剂组合物，包括以组合物的总重量为基础，约50重量％至约99.9重量％的一种或多种α-氰基丙烯酸酯单体和约0.1重量％至约5重量％的一种或多种非甾体抗炎药（NSAIDs）。适用的NSAIDs包括布洛芬和对乙酰氨基酚。与不含NSAID的组合物相比，所得到的组合物提供了增强成纤维细胞增殖和减少细胞毒性的效果。
• Cyanoacrylate compositions containing anti-microbial agent
  申请人：Closure Medical Corporation

  公开号：EP1508601A1

  公开（公告）日：2005-02-23

  A monomeric adhesive composition includes a polymerizable monomer, such as a 1,1-disubstituted monomer such as a cyanoacrylate, and an antimicrobial agent, wherein the antimicrobial agent is a phenolic active compound. Examples of suitable phenolic active compounds include halogenated phenol compounds such as chlorinated phenol compounds (such as triclosan) and brominated phenol compounds.

  单体粘合剂组合物包括可聚合单体（如氰基丙烯酸酯等 1,1-二取代单体）和抗菌剂，其中抗菌剂为酚类活性化合物。合适的酚类活性化合物包括卤代苯酚化合物，如氯代苯酚化合物（如三氯生）和溴代苯酚化合物。
• Triple antimicrobial composition
  申请人：——

  公开号：US20010016589A1

  公开（公告）日：2001-08-23

  An antimicrobial composition comprising (i) between 0.025 and 2 percent of an antimicrobial agent selected from the group consisting of chlorhexidine free base, a chlorhexidine salt, polyhexamethylene biguanide, and alexidine; (ii) between 0.005 and 0.1 percent of a quaternary ammonium compound; and (iii) between 0.025 and 2 percent of a chlorinated phenol compound.

  一种抗菌剂组合物，其成分包括：(i) 0.025%至 2%的抗菌剂，选自由洗必泰碱、洗必泰盐、聚六亚甲基双胍和阿来西啶组成的组；(ii) 0.005%至 0.1%的季铵盐化合物；以及 (iii) 0.025%至 2%的氯化酚化合物。
• Antimicrobial compositions containing colloids of oligodynamic metals
  申请人：——

  公开号：US20040116551A1

  公开（公告）日：2004-06-17

  The present invention relates to antimicrobial compositions, methods for the production of these compositions, and use of these compositions with medical devices, such as catheters, and implants. The compositions of the present invention advantageously provide varying release kinetics for the active ions in the compositions due to the different water solubilities of the ions, allowing antimicrobial release profiles to be tailored for a given application and providing for sustained antimicrobial activity over time. More particularly, the invention relates to polymer compositions containing colloids comprised of salts of one or more oligodynamic metal, such as silver. The process of the invention includes mixing a solution of one or more oligodynamic metal salts with a polymer solution or dispersion and precipitating a colloid of the salts by addition of other salts to the solution which react with some or all of the first metal salts. The compositions can be incorporated into articles or can be employed as a coating on articles such as medical devices. Coatings may be on all or part of a surface.

  本发明涉及抗菌组合物、这些组合物的生产方法以及这些组合物与医疗器械（如导管和植入物）的使用。由于活性离子的水溶性不同，本发明的组合物具有为组合物中的活性离子提供不同释放动力学的优点，从而可以为特定应用定制抗菌剂释放曲线，并提供长期持续的抗菌活性。更具体地说，本发明涉及含有由一种或多种低聚金属（如银）盐组成的胶体的聚合物组合物。本发明的工艺包括将一种或多种低聚金属盐的溶液与聚合物溶液或分散液混合，并通过向溶液中添加其他盐类沉淀盐类胶体，这些盐类胶体会与部分或全部第一种金属盐发生反应。这些组合物可以加入物品中，也可以用作医疗器械等物品的涂层。涂层可以是全部或部分表面。
• ANTIMICROBIAL COMPOSITION
  申请人：KIMBERLY-CLARK WORLDWIDE, INC.

  公开号：EP1919281A2

  公开（公告）日：2008-05-14