1-diazo-3-[2-fluoro(1,1'-biphenyl)-4-yl]-butan-2-one | 56430-64-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-diazo-3-[2-fluoro(1,1'-biphenyl)-4-yl]-butan-2-one
• 英文别名: (1E)-1-diazo-3-(3-fluoro-4-phenylphenyl)butan-2-one
• CAS: 56430-64-9
• 化学式: C₁₆H₁₃FN₂O
• 分子量: 268.29
• InChiKey: SVSKUPNUPWIRKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  19.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-氨基吡啶 、 1-diazo-3-[2-fluoro(1,1'-biphenyl)-4-yl]-butan-2-one 在 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 3.0h， 以95%的产率得到
  参考文献：
  名称：

  Cu(OTf)2-catalyzed synthesis of imidazo[1,2-a]pyridines from α-diazoketones and 2-aminopyridines

  摘要：

  -alpha-Diazoketones undergo smooth coupling with 2-aminopyridines in the presence of 10 mol % of copper(II) triflate to produce the corresponding 2-substituted imidazo[1,2-a]pyridines (IPs) in excellent yields with high selectivity. Rh-2(OAc)(4) is also found to be an equally effective catalyst for this transformation. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.08.090
• 作为产物：
  描述：

  重氮甲烷 、 flurbiprofen acid chloride 以 乙醚 为溶剂， 生成 1-diazo-3-[2-fluoro(1,1'-biphenyl)-4-yl]-butan-2-one
  参考文献：
  名称：

  First example of the coupling of α-diazoketones with thiourea: a novel route for the synthesis of 2-aminothiazoles

  摘要：

  alpha-Diazoketones undergo smooth coupling with thiourea in the presence of 10 mol % of copper(II) triflate to produce the corresponding 2-aminothiazoles in excellent yields with high selectivity. The use of copper(II) triflate makes this method simple, convenient and practical. This method works well with both aryl and alkyl diazoketones to furnish a wide range of 2-aminothiazoles. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.02.068

文献信息

• First Example of Cu(OTf)₂-catalyzed Synthesis of Quinoxalines from α-Diazoketones and Aryl 1,2-Diamines
  作者：J. S. Yadav、B. V. Subba Reddy、Y. Gopala Rao、A. V. Narsaiah

  DOI：10.1246/cl.2008.348

  日期：2008.3.5

  α-Diazoketones undergo smooth coupling with aryl 1,2-diamines in the presence of 10 mol % of copper(II) triflate to provide the corresponding 2-alkyl- or 2-aryl-quinoxalines in excellent yields wit...

  α-重氮酮在 10 mol% 三氟甲磺酸铜 (II) 存在下与芳基 1,2-二胺进行平滑偶联，以优异的收率提供相应的 2-烷基-或 2-芳基-喹喔啉...
• Geminal bisphosphonic acids and derivatives as anti-arthritic agents
  申请人：The Upjohn Company

  公开号：US05220021A1

  公开（公告）日：1993-06-15

  Unsaturated geminal phosphonates (III) ##STR1## either as the esters, free acids or salts are useful in the treatment of arthritis.

  不饱和的双亲磷酸酯(III) ##STR1## 无论是酯、自由酸或盐，都可用于治疗关节炎。
• GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS
  申请人：THE UPJOHN COMPANY

  公开号：EP0466730A1

  公开（公告）日：1992-01-22
• [EN] GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS
  申请人：THE UPJOHN COMPANY

  公开号：WO1990012017A1

  公开（公告）日：1990-10-18

  (EN) Unsaturated geminal phosphonates (III), either as the esters, free acids or salts are useful in the treatment of arthritis.(FR) L'invention concerne des phosponates germinaux insaturés (III) à titre soit d'esters, d'acides ou de sels libres utiles dans le traitement de l'arthrite.