3-phenyl-10-(pyridin-2-yl)pyrido[1,2-a]indole | 1316276-65-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-phenyl-10-(pyridin-2-yl)pyrido[1,2-a]indole
• CAS: 1316276-65-9
• 化学式: C₂₃H₁₆N₂
• 分子量: 320.393
• InChiKey: JKAKRNDSTYAAPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.82
• 重原子数：
  25.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  17.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  biphenyl-4-yldipyridin-2-ylmethanol 在 三氟甲磺酸 作用下， 以88%的产率得到3-phenyl-10-(pyridin-2-yl)pyrido[1,2-a]indole
  参考文献：
  名称：

  Charge Delocalization and Enhanced Acidity in Tricationic Superelectrophiles

  摘要：

  This Article presents the results from studies related to the chemistry of tricationic superelectrophiles. A series of triaryl methanols were ionized in Bronsted superacids, and the corresponding tricationic intermediates were formed. The trications are found to participate in two types of reactions; both are characteristic of highly charged organic cations. One set of reactions occurs through charge migration. A second set of reactions occurs through deprotonation of an unusually acidic site on the tricationic species. One of the tricationic intermediates has been directly observed by low temperature NMR spectroscopy. These highly charged ions and their reactions have also been studied using density functional theory calculations. As a result of charge migration, electron density at a carbocation site is found to increase with progression from monocationic to pentacationic structures.

  DOI：

  10.1021/ja2046364