phenyl 2-chloro-4-cyano-5-(pyrrolidin-1-yl)benzoylcarbamate | 1619236-03-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenyl 2-chloro-4-cyano-5-(pyrrolidin-1-yl)benzoylcarbamate
• CAS: 1619236-03-1
• 化学式: C₁₉H₁₆ClN₃O₃
• 分子量: 369.807
• InChiKey: GCTHPEVHCHOAJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.74
• 重原子数：
  26.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  82.43
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  6-(3-(4-methylpiperazin-1-yl)propylsulfonyl)benzo[d]thiazol-2-amine 、 phenyl 2-chloro-4-cyano-5-(pyrrolidin-1-yl)benzoylcarbamate 以 甲苯 为溶剂， 反应 0.5h， 以18%的产率得到2-chloro-4-cyano-N-(6-(3-(4-methylpiperazin-1yl)propylsulfonyl)benzo[d]thiazol-2-ylcarbamoyl)-5-(pyrrolidin-1-yl)benzamide
  参考文献：
  名称：

  Identification, Optimization, and Pharmacology of Acylurea GHS-R1a Inverse Agonists

  摘要：

  Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offer utility as antiobesity agents by lowering the set-point for hunger between meals. We identified an acylurea series of ghrelin modulators from high throughput screening and optimized binding affinity through structure activity relationship studies. Furthermore, we identified specific substructural changes, which switched partial agonist activity to inverse agonist activity, and optimized physicochemical and DMPK properties to afford the non-CNS penetrant inverse agonist 22 (AZ-GHS-22) and the CNS penetrant inverse agonist 38 (AZ-GHS-38). Free feeding efficacy experiments showed that CNS exposure was necessary to obtain reduced food intake in mice, and it was demonstrated using GHS-R1a null and wild-type mice that this effect operates through a mechanism involving GHS-R1a.

  DOI：

  10.1021/jm500610n
• 作为产物：
  描述：

  2-chloro-4-cyano-5-fluorobenzamide 在 sodium hydride 作用下， 以 四氢呋喃 、 N-甲基吡咯烷酮 为溶剂， 反应 4.5h， 生成 phenyl 2-chloro-4-cyano-5-(pyrrolidin-1-yl)benzoylcarbamate
  参考文献：
  名称：

  Identification, Optimization, and Pharmacology of Acylurea GHS-R1a Inverse Agonists

  摘要：

  Ghrelin plays a major physiological role in the control of food intake, and inverse agonists of the ghrelin receptor (GHS-R1a) are widely considered to offer utility as antiobesity agents by lowering the set-point for hunger between meals. We identified an acylurea series of ghrelin modulators from high throughput screening and optimized binding affinity through structure activity relationship studies. Furthermore, we identified specific substructural changes, which switched partial agonist activity to inverse agonist activity, and optimized physicochemical and DMPK properties to afford the non-CNS penetrant inverse agonist 22 (AZ-GHS-22) and the CNS penetrant inverse agonist 38 (AZ-GHS-38). Free feeding efficacy experiments showed that CNS exposure was necessary to obtain reduced food intake in mice, and it was demonstrated using GHS-R1a null and wild-type mice that this effect operates through a mechanism involving GHS-R1a.

  DOI：

  10.1021/jm500610n