(Z)-3-chloro-N-[(S)-1-hydroxy-3,3-phenylpropan-2-yl]-2-(benzenesulfinyl)acrylamide | 1240349-94-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-3-chloro-N-[(S)-1-hydroxy-3,3-phenylpropan-2-yl]-2-(benzenesulfinyl)acrylamide
• 英文别名: (Z)-2-(benzenesulfinyl)-3-chloro-N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]prop-2-enamide
• CAS: 1240349-94-3
• 化学式: C₁₈H₁₈ClNO₃S
• 分子量: 363.865
• InChiKey: RDEGJWOXUHRSOY-OLFWADDNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  85.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (Z)-N-[(S)-1-hydroxy-3-phenylprop-2-yl]-3-chloro-2-(phenylthio)propenamide 在 potassium peroxomonosulfate 作用下， 以 水 、 丙酮 为溶剂， 反应 2.0h， 以95%的产率得到(Z)-3-chloro-N-[(S)-1-hydroxy-3,3-phenylpropan-2-yl]-2-(benzenesulfinyl)acrylamide
  参考文献：
  名称：

  Diastereoselective sulfur oxidation of 2-thio-3-chloroacrylamides

  摘要：

  Diastereoselective sulfur oxidation in 2-thio-3-chloroacrylamides is described A range of chiral amine auxiliaries was incorporated in the beta-chloroacrylamide, and the efficiency with which the stereochemistry was relayed to the sulfur centre during sulfoxidation was investigated. Diastereomeric ratios of up to 3 3 1 were achieved. (C) 2010 Elsevier Ltd. All rights reserved

  DOI：

  10.1016/j.tetasy.2010.05.004

文献信息

• Diastereoselective sulfur oxidation of 2-thio-3-chloroacrylamides
  作者：Marie Kissane、Simon E. Lawrence、Anita R. Maguire

  DOI：10.1016/j.tetasy.2010.05.004

  日期：2010.4

  Diastereoselective sulfur oxidation in 2-thio-3-chloroacrylamides is described A range of chiral amine auxiliaries was incorporated in the beta-chloroacrylamide, and the efficiency with which the stereochemistry was relayed to the sulfur centre during sulfoxidation was investigated. Diastereomeric ratios of up to 3 3 1 were achieved. (C) 2010 Elsevier Ltd. All rights reserved