N-((5,6-dihydro-4H-pyran-3-yl)(phenyl)methyl)-4-(dimethylamino)benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-((5,6-dihydro-4H-pyran-3-yl)(phenyl)methyl)-4-(dimethylamino)benzamide
• 英文别名: N-[3,4-dihydro-2H-pyran-5-yl(phenyl)methyl]-4-(dimethylamino)benzamide
• 化学式: C₂₁H₂₄N₂O₂
• 分子量: 336.434
• InChiKey: IQJZILWPZLUABC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,4-二氢-2H-吡喃 、 N-benzylidene-4-(dimethylamino)benzamide 在 苯膦酸 作用下， 以 氯仿 为溶剂， 生成 N-((5,6-dihydro-4H-pyran-3-yl)(phenyl)methyl)-4-(dimethylamino)benzamide
  参考文献：
  名称：

  Chiral Phosphoric Acid Catalyzed Addition of Dihydropyrans to N-Acyl Imines: Stereocontrolled Access to Enantioenriched Spirocyclic Oxazoletetrahydropyrans with Three Contiguous Stereocenters

  摘要：

  Dihydropyran derivatives readily undergo addition to N-acyl imines in the presence of chiral phosphoric acids. This addition process yields an attractive product that is capable of a tandem oxidative-cyclization via an epoxide intermediate.

  DOI：

  10.1021/ol100378t

文献信息

• Chiral Phosphoric Acid Catalyzed Addition of Dihydropyrans to <i>N</i>-Acyl Imines: Stereocontrolled Access to Enantioenriched Spirocyclic Oxazoletetrahydropyrans with Three Contiguous Stereocenters
  作者：Guilong Li、Matthew J. Kaplan、Lukasz Wojtas、Jon C. Antilla

  DOI：10.1021/ol100378t

  日期：2010.5.7

  Dihydropyran derivatives readily undergo addition to N-acyl imines in the presence of chiral phosphoric acids. This addition process yields an attractive product that is capable of a tandem oxidative-cyclization via an epoxide intermediate.