4-(4-(氨基甲基)-3-甲氧基苯氧基)丁酸 | 213120-60-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(4-(氨基甲基)-3-甲氧基苯氧基)丁酸
• 英文名称: 4-(4-(Aminomethyl)-3-methoxyphenoxy)butanoic acid
• 英文别名: 4-[4-(aminomethyl)-3-methoxyphenoxy]butanoic acid
• CAS: 213120-60-6
• 化学式: C₁₂H₁₇NO₄
• 分子量: 239.27
• InChiKey: YCGXOVXLBIYWOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  81.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Process for the preparation of liraglutide
  申请人：Auro Peptides Ltd

  公开号：US10344069B2

  公开（公告）日：2019-07-09

  The present invention relates to a process for the preparation of Liraglutide, which comprises: a) synthesis of suitable fragments (protected) by solid phase peptide synthesis; b) coupling of the suitable fragments on solid support; c) concurrently cleaving the protected peptide from the solid support and de-protecting the peptide; d) purification of Liraglutide (crude) on reverse phase HPLC; e) isolating pure Liraglutide.

  本发明涉及一种制备利拉鲁肽的工艺，该工艺包括：a) 通过固相肽合成法合成合适的片段（受保护的）；b) 将合适的片段偶联在固体支持物上；c) 同时将受保护的肽从固体支持物上裂解并去保护肽；d) 在反相高效液相色谱法上纯化利拉鲁肽（粗品）；e) 分离出纯净的利拉鲁肽。
• A PROCESS FOR THE PREPARATION OF LINACLOTIDE
  申请人：Auro Peptides LTD

  公开号：EP3191503A1

  公开（公告）日：2017-07-19
• PROCESS FOR THE PREPARATION OF LIRAGLUTIDE
  申请人：SURESH KUMAR Vadlamami

  公开号：US20180251511A1

  公开（公告）日：2018-09-06

  The present invention relates to a process for the preparation of Liraglutide, which comprises: a) synthesis of suitable fragments (protected) by solid phase peptide synthesis; b) coupling of the suitable fragments on solid support; c) concurrently cleaving the protected peptide from the solid support and de-protecting the peptide; d) purification of Liraglutide (crude) on reverse phase HPLC; e) isolating pure Liraglutide.
• [EN] A PROCESS FOR THE PREPARATION OF LINACLOTIDE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE LINACLOTIDE
  申请人：AURO PEPTIDES LTD

  公开号：WO2016038497A1

  公开（公告）日：2016-03-17

  The present invention relates to a process for the preparation of Linaclotide by oxidizing linear Linaclotide of formula (II) using combination of air and oxidizing agent followed by purification using RP-HPLC.
• [EN] A PROCESS FOR THE PREPARATION OF LIRAGLUTIDE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE LIRAGLUTIDE
  申请人：AURO PEPTIDES LTD

  公开号：WO2016067271A1

  公开（公告）日：2016-05-06

  The present invention relates to a process for the preparation of Liraglutide, which comprises: a) synthesis of suitable fragments (protected) by solid phase peptide synthesis; b) coupling of the suitable fragments on solid support; c) concurrently cleaving the protected peptide from the solid support and de- protecting the peptide; d) purification of Liraglutide (crude) on reverse phase HPLC; e) isolating pure Liraglutide.