(S)-3-(4-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzylamino)-6-cyano-N-(1-(3,4-difluorophenyl)ethyl)pyrazine-2-carboxamide | 1289179-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (S)-3-(4-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzylamino)-6-cyano-N-(1-(3,4-difluorophenyl)ethyl)pyrazine-2-carboxamide
• 英文别名: US10030016, Example 27；3-[[4-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)phenyl]methylamino]-6-cyano-N-[(1S)-1-(3,4-difluorophenyl)ethyl]pyrazine-2-carboxamide
• CAS: 1289179-35-6
• 化学式: C₂₈H₂₃F₂N₉O
• 分子量: 539.547
• InChiKey: FZFUHDBXSVKESO-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  40
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  147
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS
  申请人：Arndt Joseph

  公开号：US20120208819A1

  公开（公告）日：2012-08-16

  The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.

  本发明提供了作为PDK1抑制剂有用的化合物。本发明还提供了它们的组合物，以及治疗PDK1介导的疾病的方法。
• HETEROCYCLIC PDK1 INHIBITORS FOR USE TO TREAT CANCER
  申请人：Sunesis Pharmaceuticals, Inc.

  公开号：EP3763368A1

  公开（公告）日：2021-01-13

  Described are methods of use of compounds that inhibit PIF-mediated substrate binding by PDK1, which are useful as inhibitors of cancer growth or proliferation that is RSK2-dependent or AKT-independent. Also described are compositions of such compounds for use in such methods of treating cancer.

  描述了抑制 PIF 介导的底物与 PDK1 结合的化合物的使用方法，这些化合物可用作 RSK2 依赖性或 AKT 非依赖性癌症生长或增殖的抑制剂。还描述了用于此类治疗癌症方法的此类化合物的组合物。
• Heterocyclic compounds useful as PDK1 inhibitors
  申请人：Sunesis Pharmaceuticals, Inc.

  公开号：US10030016B2

  公开（公告）日：2018-07-24

  The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.

  本发明提供了可用作 PDK1 抑制剂的化合物。 本发明还提供了其组合物以及治疗 PDK1 介导的疾病的方法。
• US9546165B2
  申请人：——

  公开号：US9546165B2

  公开（公告）日：2017-01-17
• [EN] HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS<br/>[FR] COMPOSES HETEROCYCLIQUES UTILISES COMME INHIBITEURS DE PDK1
  申请人：BIOGEN IDEC INC

  公开号：WO2011044157A1

  公开（公告）日：2011-04-14

  The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.