2-Methylguanidino-4,6-dimethylpyrimidin | 55474-83-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-Methylguanidino-4,6-dimethylpyrimidin
• 英文别名: N-(4,6-dimethyl-pyrimidin-2-yl)-N'-methyl-guanidine；1-(4,6-Dimethylpyrimidin-2-yl)-2-methylguanidine
• CAS: 55474-83-4
• 化学式: C₈H₁₃N₅
• 分子量: 179.225
• InChiKey: OAKUDRMFOQZUSC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  76.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS
  申请人：The Board of Regents of the University of Texas System

  公开号：US20160220510A1

  公开（公告）日：2016-08-04

  An aminoacylation/translation (AIT) system based on the protein synthesis system from the pathogen Pseudomonas aeruginosa , was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: EF-Tu, EF-Ts and EF-G, aminoacyl tRNA synthetase (aaRS) specific for phenylalanine, PheRS, and ribosomes isolated from cultures of Pseudomonas aeruginosa . Compounds identified using this assay have been shown to contain broad spectrum activity against both Gram+ and Gram− pathogens. Methods of using the identified compounds, as well as derivatives and analogues of these compounds, as antimicrobial agents against bacterial infections are described.