2,3-dichloro-4-methoxybenzophenone | 85893-74-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-dichloro-4-methoxybenzophenone
• 英文别名: 2,3-Dichloro-4-benzoylanisole；(2,3-dichloro-4-methoxyphenyl)-phenylmethanone
• CAS: 85893-74-9
• 化学式: C₁₄H₁₀Cl₂O₂
• 分子量: 281.138
• InChiKey: MEZLFEBZUZORBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3-dichloro-4-methoxybenzophenone 在 氨 、 sulfur 作用下， 以 乙二醇二甲醚 为溶剂， 反应 13.0h， 以34%的产率得到7-chloro-6-methoxy-3-phenylbenzisothiazole
  参考文献：
  名称：

  Heterocyclic oxyacetic acid diuretics: indazole, benzisothiazole, and benzisothiazole 1,1-dioxide analogs of [[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy]acetic acid

  摘要：

  The indazole, benzisothiazole, and benzisothiazole 1,1-dioxide analogues of [[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy]acetic acid were synthesized and tested for diuretic activity in saline-loaded mice. Each analogue was found to be less active than the parent benzisoxazole: the diuretic activity followed the order O greater than S greater than N = SO2 in regard to the heteroatom in the 1-position of the ring.

  DOI：

  10.1021/jm00363a016
• 作为产物：
  描述：

  2,3-二氯茴香醚 、 苯甲酰氯 、 三氯化铝 生成 2,3-dichloro-4-methoxybenzophenone
  参考文献：
  名称：

  IMAKI, KATSUHIRO;OKEGAWA, TADAO;ARAI, YOSHINOBU

  摘要：

  DOI：

文献信息

• 3-[(4-Aroyl) phenoxy (or phenylthio)]-cyclopentanecarboxylic acid
  申请人：Ono Pharmaceutical Co., Ltd.

  公开号：US04916147A1

  公开（公告）日：1990-04-10

  Novel compounds of the general formula: ##STR1## [wherein X represents an oxygen atom or sulfur atom, R.sup.1, R.sup.2 and R.sup.3 represent a hydrogen atom, a halogen atom or an alkyl group of from 1 to 4 carbon atom(s) independently or a formula: R.sup.3' ##STR2## (wherein R.sup.3' represents a hydrogen atom or an alkyl group of from 1 to 4 carbon(s)) in place of a formula: ##STR3## R.sup.4 represents a general formula: ##STR4## or --N(R.sup.9).sub.2 (in which W represents an oxygen atom or sulfur atom, R.sup.6, R.sup.7 and R.sup.8 represent a hydrogen atom, a halogen atom, a nitro group, an alkyl group of from 1 to 4 carbon atom(s), a hydroxy group or an alkoxy group of from 1 to 4 carbon atom(s) independently, each of R.sup.9 represents a hydrogen atom, an alkyl group of from 1 to 4 carbon atom(s) or a phenyl group and Y represents a single bond or an alkylene group or an alkenylene group of from 1 to 4 carbon atom(s).), and R.sup.5 represents a 5-tetrazolyl group or a general formula: --COOR.sup.10 (in which R.sup.10 represents a hydrogen atom or an alkyl group of from 1 to 4 carbon atom(s))] and non-toxic salts possess inhibitory effect on cerebral edema.

  通式为：##STR1##的新化合物[其中X代表氧原子或硫原子，R.sup.1、R.sup.2和R.sup.3分别独立地代表氢原子、卤素原子或1至4个碳原子的烷基或公式：R.sup.3'##STR2##（其中R.sup.3'代表氢原子或1至4个碳原子的烷基）代替公式：##STR3##，R.sup.4代表以下通式：##STR4##或--N(R.sup.9).sub.2（其中W代表氧原子或硫原子，R.sup.6、R.sup.7和R.sup.8独立地代表氢原子、卤素原子、硝基、1至4个碳原子的烷基、羟基或1至4个碳原子的烷氧基，每个R.sup.9代表氢原子、1至4个碳原子的烷基或苯基，Y代表单键或1至4个碳原子的烷基或烯基烷基），R.sup.5代表5-四唑基基团或以下通式：--COOR.sup.10（其中R.sup.10代表氢原子或1至4个碳原子的烷基）]和无毒盐具有抑制脑水肿的作用。
• Process for preparing tritylated polystylene resin
  申请人：——

  公开号：US20030105243A1

  公开（公告）日：2003-06-05

  The present invention relates to a process for preparing tritylated polystyrene resin. More particularly, the present invention is directed to a process for preparing tritylated polystyrene resins, comprising a step for tritylating polystyrene by reacting polystyrene resin with benzophenone dichloride or substituted benzophenone dichloride to introduce trityl group on the benzene moiety of the polystyrene.

  本发明涉及一种制备三苯甲基化聚苯乙烯树脂的方法。更具体地说，本发明涉及一种制备三苯甲基化聚苯乙烯树脂的方法，包括通过将聚苯乙烯树脂与苯并苯酮二氯化物或取代苯并苯酮二氯化物反应来在聚苯乙烯的苯环上引入三苯甲基基团的步骤。
• 3-[(4-Aroyl)phenoxy(or phenylthio)]cyclopentanecarboxylic acid analogues
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP0210772A2

  公开（公告）日：1987-02-04

  Novel compounds of the general formula: (wherein R3 represents a hydrogen atom, a halogen atom or an alkyl group of from 1 to 4 carbon atom(s).) in place of a formula: , R4 represents a general formula: or -N(R9)2 (in which W represents an oxygen atom or sulfur atom, R6, R7 and R8 represent a hydrogen atom, a halogen atom, a nitro group, an alkyl group of from 1 to 4 carbon atom(s), a hydroxy group or an alkoxy group of from 1 to 4 carbon atom(s) independently, each of R9 represents a hydrogen atom, an alkyl group of from 1 to 4 carbon atom(s) or a phenyl groups and Y represents a single bond or an alkylene group or an alkenylene group of from 1 to 4 carbon atom(s).), and R6 represents a 5-tetrazolyl group or a general formula: -COOR10 (in which R10 represents a hydrogen atom or an alkyl group of from 1 to 4 carbon atom(s).)] and non-toxic salts possess inhibitory effect on cerebral edema.

  通式如下的新型化合物 (其中 R3 代表氢原子、卤素原子或 1 至 4 个碳原子的烷基）代替通式 ，R4 代表通式 或-N(R9)2（其中 W 代表氧原子或硫原子，R6、R7 和 R8 分别代表氢原子、卤素原子、硝基、1 至 4 个碳原子的烷基、羟基或 1 至 4 个碳原子的烷氧基、R9 分别代表氢原子、1 至 4 个碳原子的烷基或苯基，Y 代表单键或 1 至 4 个碳原子的亚烷基或烯基。)，R6 代表 5-四唑基或通式：-COOR10（其中 R10 代表氢原子或 1 至 4 个碳原子的烷基）]和无毒盐具有抑制脑水肿的作用。
• Process for preparing trityl group containing polystyrene resins
  申请人：Beadtech Inc.

  公开号：EP1314745A1

  公开（公告）日：2003-05-28

  The present invention relates to a process for preparing tritylated polystyrene resin. More particularly, the present invention is directed to a process for preparing tritylated polystyrene resins, comprising a step for tritylating polystyrene by reacting polystyrene resin with benzophenone dichloride or substituted benzophenone dichloride to introduce trityl group on the benzene moiety of the polystyrene.

  本发明涉及一种制备三苯甲基化聚苯乙烯树脂的工艺。更具体地说，本发明涉及一种制备三苯甲基化聚苯乙烯树脂的工艺，包括将聚苯乙烯树脂与二氯二苯甲酮或取代的二氯二苯甲酮反应，在聚苯乙烯的苯基上引入三苯甲基，从而三苯甲基化聚苯乙烯的步骤。
• IMAKI, KATSUXIRO;OKEHGAVA, TADAO;ARAI, JOSINOBU
  作者：IMAKI, KATSUXIRO、OKEHGAVA, TADAO、ARAI, JOSINOBU

  DOI：——

  日期：——