N-(2-acetamidoethyl)-12-phenyl-5,6,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1(13),2,4,9,11-pentaene-4-carboxamide | 1221884-98-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(2-acetamidoethyl)-12-phenyl-5,6,11,13-tetrazatricyclo[7.4.0.02,6]trideca-1(13),2,4,9,11-pentaene-4-carboxamide
• CAS: 1221884-98-5
• 化学式: C₂₀H₂₀N₆O₂
• 分子量: 376.418
• InChiKey: CKIBHBBHTIZEQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] TETRA-AZA-HETEROCYCLES AS PHOSPHATIDYLINOSITOL-3-KINASES (PI3-KINASES) INHIBITOR<br/>[FR] TÉTRA-AZA-HÉTÉROCYCLES COMME INHIBITEUR DE PHOSPHATIDYLINOSITOL-3-KINASES (PI3-KINASES)
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2010043676A1

  公开（公告）日：2010-04-22

  The present invention encompasses compounds of general formula (1) wherein R1 to R4, A, X, m and k are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

  本发明涵盖了一般式（1）中R1至R4、A、X、m和k的定义如权利要求书中所述的化合物，适用于治疗以细胞过度或异常增殖为特征的疾病，并用于制备具有上述特性的药物。
• TETRA-AZA-HETEROCYCLES AS PHOSPHATIDYLINOSITOL-3-KINASES (P13-KINASES) INHIBITOR
  申请人：Van Der Veen Lars

  公开号：US20110312940A1

  公开（公告）日：2011-12-22

  The present invention encompasses compounds of general formula (1) wherein R 1 to R 4 , A, X, m and k are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

  本发明涵盖了通式（1）中R1至R4，A，X，m和k如权利要求1所定义的化合物，适用于治疗由过度或异常细胞增殖所表征的疾病，并用于制备具有上述特性的药物。
• TETRA-AZA-HETEROCYCLES AS PHOSPHATIDYLINOSITOL-3-KINASES (PI3-KINASES) INHIBITOR
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2350084B1

  公开（公告）日：2015-06-24
• US8653097B2
  申请人：——

  公开号：US8653097B2

  公开（公告）日：2014-02-18