O-[2-(tert-butyldisulfanyl)ethyl]hydroxylamine | 1221405-60-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 有机二硫化物
• 英文名称: O-[2-(tert-butyldisulfanyl)ethyl]hydroxylamine
• CAS: 1221405-60-2
• 化学式: C₆H₁₅NOS₂
• 分子量: 181.323
• InChiKey: KHNWLWMHYHVORV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  85.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  O-[2-(tert-butyldisulfanyl)ethyl]hydroxylamine 、 D-methyl 2-trifluoromethanesulfonyl-3-phenyllactate 生成 methyl (2S)-2-[2-(tert-butyldisulfanyl)ethoxyamino]-3-phenylpropanoate
  参考文献：
  名称：

  Peptide ligation assisted by an auxiliary attached to amidyl nitrogen

  摘要：

  New thiol-containing auxiliaries were developed for peptide ligation. They were placed at the amidyl N-atom in the second amino acid residue of a peptide fragment. With the new auxiliaries, peptide ligation could be conducted at non-Cys and non-Gly sites. Compared to other recently developed auxiliaries, an important feature of the present design was that the new auxiliaries were generally applicable and readily removable. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.108
• 作为产物：
  描述：

  2-Aminooxy-aethylmercaptan 、 叔丁基硫醇 在 碘 作用下， 生成 O-[2-(tert-butyldisulfanyl)ethyl]hydroxylamine
  参考文献：
  名称：

  Peptide ligation assisted by an auxiliary attached to amidyl nitrogen

  摘要：

  New thiol-containing auxiliaries were developed for peptide ligation. They were placed at the amidyl N-atom in the second amino acid residue of a peptide fragment. With the new auxiliaries, peptide ligation could be conducted at non-Cys and non-Gly sites. Compared to other recently developed auxiliaries, an important feature of the present design was that the new auxiliaries were generally applicable and readily removable. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.01.108

文献信息

• Peptide ligation assisted by an auxiliary attached to amidyl nitrogen
  作者：Juan Li、Hong-Kui Cui、Lei Liu

  DOI：10.1016/j.tetlet.2010.01.108

  日期：2010.3

  New thiol-containing auxiliaries were developed for peptide ligation. They were placed at the amidyl N-atom in the second amino acid residue of a peptide fragment. With the new auxiliaries, peptide ligation could be conducted at non-Cys and non-Gly sites. Compared to other recently developed auxiliaries, an important feature of the present design was that the new auxiliaries were generally applicable and readily removable. (C) 2010 Elsevier Ltd. All rights reserved.