methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate;sulfuric acid | 1656990-76-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate;sulfuric acid
• CAS: 1656990-76-9
• 化学式: C12H17N3O6S2
• 分子量: 363.4
• InChiKey: JKMJAZXGMHMQOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.59
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  175
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• METHOD FOR TREATMENT OF CANCER AND COMPOSITIONS FOR USE THEREIN
  申请人：UNISEARCH LIMITED

  公开号：EP1379242A1

  公开（公告）日：2004-01-14
• EP1379242A4
  申请人：——

  公开号：EP1379242A4

  公开（公告）日：2007-10-03
• [EN] METHOD FOR TREATMENT OF CANCER AND COMPOSITIONS FOR USE THEREIN<br/>[FR] METHODE DE TRAITEMENT DE CANCERS ET COMPOSITIONS APPROPRIEES
  申请人：UNISEARCH LTD

  公开号：WO2002076454A1

  公开（公告）日：2002-10-03

  The present invention provides a method for the treatment of a tumor in a subject. The method comprises administering to the subject a composition comprising a therapeutically effective amount of a compound of Formula (I), wherein R1 is selected from H, substituted or unsubstituted, straight or branch chain alkyl, alkenyl, alkenylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkenylalkyl, aryl, arylalkyl, -SR7, -SOR8, -SO2R9, -SCN, B'(CH2)nBR10, -C(O)-R11 or -OR12, COOR13, -NO2, NR13aCOOR13b, isothiocyanato, or -CN where R7 to R13b are each independently selected from H, substituted or unsubstituted, straight or branch chain alkyl, alkenyl, alkenylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkenylalkyl, aryl, arylalkyl, B and B' are independently selected from O, S, S(O) or SO2 and n is 1 to 4; R2 is selected from H, or substituted or unsubstituted alkyl. R3 is selected from H, substituted or unsubstituted, straight or branch chain alkyl, alkenyl, alkenylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkenylalkyl, aryl, arylalkyl, 5- or 6- membered heterocyclic ring the heteroatom(s) of which are selected from one of more of O, S and/or N, -SR14, -OR15, -SOR16, -SO2R17, -SCN, -C(O)-R18, -OR19, NR20COOR21, where R15 to R21 are each independently selected from H, substituted or unsubstituted, straight or branch chain alkyl, alkenyl, alkenylalkyl, cycloalkyl, cycloalkylalkyl, cycloalkenylalkyl, aryl or arylalkyl; or an analogue or metabolite thereof.