N,N'-Bis(diphenylphosphino)-N,N'-bis[(R)-1-phenylethyl]-ethylenediamine | 65903-48-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N'-Bis(diphenylphosphino)-N,N'-bis[(R)-1-phenylethyl]-ethylenediamine
• 英文别名: N,N'-bis(diphenylphosphanyl)-N,N'-bis[(1R)-1-phenylethyl]ethane-1,2-diamine
• CAS: 65903-48-2
• 化学式: C₄₂H₄₂N₂P₂
• 分子量: 636.756
• InChiKey: TYRRWPJYBCYJPG-LQFQNGICSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.1
• 重原子数：
  46
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Novel olefination process to itaconate and succinate derivatives
  申请人：——

  公开号：US20020188121A1

  公开（公告）日：2002-12-12

  An efficient and selective process, capable of scale-up, to make itaconate derivatives of formula (IV), and/or succinate derivatives of formula (V) and/or (VI) by asymmetric hydrogenation of the itaconate derivatives. 1 wherein R, R 1 and R 2 are as defined herein.

  一种高效且选择性的工艺，可进行放大，通过对顺丁烯二酸衍生物进行不对称加氢，制备式（IV）的顺丁烯二酸衍生物，以及式（V）和/或式（VI）的丁二酸衍生物。其中R，R1和R2的定义如本文所述。
• Process for preparing amino acids and their esters
  申请人：ANIC S.p.A.

  公开号：EP0077099A2

  公开（公告）日：1983-04-20

  An improved process is described for preparing amino acids with high optical yield, the process being based on an Initial asymmetric hydrogenation of a suitable olefin-unsaturated prochiral or raceme compound, for example alpha-acetamido cinnamic acid in the case of L-N,acetylphenylalanine, in the presence of a catalyst constituted by a compound of a transition metal with asymmetric aminophosphines, in particular a rhodium complex. The hydrogenation reaction is followed by treating the final product with a solvent mixture constituted by an alcohol and a halogenated hydrocarbon, which favours the removal of the catalyst residue and simultaneously increases the optical yield of the required amino acid. The invention also provides for the preparation of amino acid esters from the corresponding N-acylamino acids without the intermediate separation of the relative amino acid. The transformation takes place in a single step which comprises the deacylation of the amino group and the esterification of the carboxyl function, in the presence of a catalyst.

  本发明描述了一种用于制备高光学产率氨基酸的改进工艺，该工艺基于合适的烯烃不饱和亲手性或外消旋化合物的初始不对称氢化反应，例如 L-N，乙酰基苯丙氨酸的α-乙酰氨基肉桂酸，催化剂由过渡金属与不对称氨基膦的化合物构成，特别是铑络合物。氢化反应后，用醇和卤代烃构成的溶剂混合物处理最终产物，这有利于去除催化剂残留物，同时提高所需氨基酸的光学产率。本发明还提供了从相应的 N-酰基氨基酸制备氨基酸酯的方法，中间无需分离相对的氨基酸。在催化剂存在的情况下，转化只需一步，包括氨基的脱乙酰化和羧基官能团的酯化。
• Process for preparing optically active cyclohexanol derivatives
  申请人：Takasago International Corporation

  公开号：EP0768288A2

  公开（公告）日：1997-04-16

  A process for producing an optically active cyclohexanol derivative represented by formula (I): wherein R1 represents an alkyl group having 1 to 4 carbon atoms, a hydroxyl group, or a protected hydroxyl group, comprising asymmetrically hydrogenating a cyclohexanone derivative in the presence of a catalyst system composed of a transition metal compound, for example, transition metal complex, a base such as KOH, and a nitrogen compound for example, an amine compound. Such cyclohexanol derivatives are useful in various applications for example as intermediate for pharmaceuticals or optically active ligands.

  一种生产由式(I)代表的光学活性环己醇衍生物的工艺： 其中 R1 代表具有 1 至 4 个碳原子的烷基、羟基或受保护的羟基，包括在由过渡金属化合物（例如过渡金属络合物）、碱（例如 KOH）和氮化合物（例如胺化合物）组成的催化剂体系存在下，不对称地氢化环己酮衍生物。这种环己醇衍生物有多种用途，例如可用作药物或光学活性配体的中间体。
• Process for producing optically active benzhydrol compounds
  申请人：Takasago International Corporation

  公开号：EP0781749A2

  公开（公告）日：1997-07-02

  A process for producing a benzhydrol compound (II) which comprises hydrogenating a benzophenone compound (I) in the presence of a hydrogenation catalyst consisting of a transition metal complex, a base and an optically active diamine compound: wherein R1 to R10 each represents H, OH, C1-4 alkyl, C1-4 alkoxy, C1-4 alkanoyl, etc., R2 and R3, and R8 and R9 may form -CH=CH-CH=CH-, or any two of R1 to R9 adjacent to each other may be bonded to thereby form -OCH2O- or -(CH2)3-. By using this process, optically active benzhydrol compounds which have a high purity and are useful as, for example, intermediates in the synthesis of drugs can be produced by simple procedures.

  一种生产苯海醇化合物（II）的工艺，包括在由过渡金属络合物、碱和光学活性二胺化合物组成的氢化催化剂存在下氢化二苯甲酮化合物（I）： 其中R1至R10各自代表H、OH、C1-4烷基、C1-4烷氧基、C1-4烷酰基等，R2和R3以及R8和R9可形成-CH＝CH-CH＝CH-，或相邻的任何两个R1至R9可键合从而形成-O O-或-(CH2)3-。使用这种工艺，可以通过简单的程序生产出纯度高、可用作药物合成中间体等的光学活性二苯基甲醇化合物。
• Olefination process to itaconate and succinate derivatives
  申请人：Pfizer Limited

  公开号：EP1199301A1

  公开（公告）日：2002-04-24

  An efficient and selective process, capable of scale-up, to make itaconate derivatives of formula (IV), and/or succinate derivatives of formula (V) and/or (VI) by asymmetric hydrogenation of the itaconate derivatives. The process comprises formation of a compound of formula (IV) by reaction of an aldehyde of formula RCHO with a phosphorus compound of formula (IX): or a metal carboxylate optionally followed by, if a compound of formula (V) or (VI) is desired, asymmetric reduction of a compound of formula (IV) to provide a compound of formula (V) or (VI)

  一种高效且具有选择性的工艺，可通过对伊塔康酸衍生物进行不对称氢化，制得式(IV)的伊塔康酸衍生物和/或式(V)和/或式(VI)的琥珀酸衍生物。 该工艺包括 式 RCHO 的醛与式 (IX) 的磷化合物反应生成式 (IV) 的化合物： 或金属羧酸盐 如果需要式（V）或（VI）化合物，可选择随后进行式（IV）化合物的不对称还原，以提供式（V）或（VI）化合物