2-(1H-indol-3-yl)-4-(2-phenylphenyl)-6-pyridin-2-ylpyridine-3-carbonitrile | 1174045-89-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(1H-indol-3-yl)-4-(2-phenylphenyl)-6-pyridin-2-ylpyridine-3-carbonitrile
• CAS: 1174045-89-6
• 化学式: C₃₁H₂₀N₄
• 分子量: 448.527
• InChiKey: SUBXGZQQGXLKJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-乙酰基吡啶 、 联苯-2-甲醛 、 3-(1H-吲哚-3-基)-3-氧丙腈 在 ammonium acetate 作用下， 反应 0.3h， 以90%的产率得到2-(1H-indol-3-yl)-4-(2-phenylphenyl)-6-pyridin-2-ylpyridine-3-carbonitrile
  参考文献：
  名称：

  A simple one-pot synthesis of functionalised 6-(indol-3-yl)-2,2′-bipyridine derivatives via multi-component reaction under neat condition

  摘要：

  A series of 4-aryl-6-(1H-indol-3-yl)-2,2-bipyridine-5-carbonitrile derivatives were synthesized via a one-pot multi-component reaction of aromatic aldehydes, 3-(cyanoacetyl)indole and 2-acetyl pyridine in ammonium acetate by conventional heating and microwave irradiation under solvent-free condition. Also a series of 6,6'-di(1H-indol-3-yl)-4,4'-diaryl-2,2'-bipyridine-5,5'-dicarbonitrile derivatives were synthesized using cinnamils, 3-(cyanoacetyl)indole and ammonium acetate. The methodology affords high yields of product at short reaction time. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.04.121

文献信息

• A simple one-pot synthesis of functionalised 6-(indol-3-yl)-2,2′-bipyridine derivatives via multi-component reaction under neat condition
  作者：Prakasam Thirumurugan、Paramasivan T. Perumal

  DOI：10.1016/j.tetlet.2009.04.121

  日期：2009.7

  A series of 4-aryl-6-(1H-indol-3-yl)-2,2-bipyridine-5-carbonitrile derivatives were synthesized via a one-pot multi-component reaction of aromatic aldehydes, 3-(cyanoacetyl)indole and 2-acetyl pyridine in ammonium acetate by conventional heating and microwave irradiation under solvent-free condition. Also a series of 6,6'-di(1H-indol-3-yl)-4,4'-diaryl-2,2'-bipyridine-5,5'-dicarbonitrile derivatives were synthesized using cinnamils, 3-(cyanoacetyl)indole and ammonium acetate. The methodology affords high yields of product at short reaction time. (C) 2009 Elsevier Ltd. All rights reserved.