methyl 6-methyl-1,8-naphthyridine-3-carboxylate | 1173104-68-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: methyl 6-methyl-1,8-naphthyridine-3-carboxylate
• 英文别名: Methyl 6-methyl-1,8-naphthyridine-3-carboxylate
• CAS: 1173104-68-1
• 化学式: C₁₁H₁₀N₂O₂
• 分子量: 202.213
• InChiKey: CZMHJEZDNZHBDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  52.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-[Acetoxy-(2-chloro-5-methyl-pyridin-3-yl)-methyl]-acrylic acid methyl ester 在 potassium carbonate 、 对甲苯磺酰胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以64%的产率得到methyl 6-methyl-1,8-naphthyridine-3-carboxylate
  参考文献：
  名称：

  由取代的2-氯烟碱醛的Baylis-Hillman加合物合成取代的1,8-萘啶-3-羧酸盐

  摘要：

  Abstractmagnified imageA series of substituted 1,8‐naphthyridine‐3‐carboxylates were synthesized for the first time from the Baylis–Hillman adducts obtained from 2‐chloronicotinaldehyde derivatives. Three methods were adopted to synthesize 1,8‐naphthyridine‐3‐carboxylates, of which the azide‐reduction route (Scheme 5) gave the best yields compared to the other attempted methods (Schemes 2 and 3).

  DOI：

  10.1002/hlca.200800352

文献信息

• Synthesis of Substituted 1,8-Naphthyridine-3-carboxylates from<i>Baylis-Hillman</i>Adducts of Substituted 2-Chloronicotinaldehydes
  作者：Puli Narender、Mettu Ravinder、Partha Sarathi Sadhu、Bhimapaka China Raju、Chilukuri Ramesh、Vaidya Jayathirtha Rao

  DOI：10.1002/hlca.200800352

  日期：2009.5

  Abstractmagnified imageA series of substituted 1,8‐naphthyridine‐3‐carboxylates were synthesized for the first time from the Baylis–Hillman adducts obtained from 2‐chloronicotinaldehyde derivatives. Three methods were adopted to synthesize 1,8‐naphthyridine‐3‐carboxylates, of which the azide‐reduction route (Scheme 5) gave the best yields compared to the other attempted methods (Schemes 2 and 3).