diethyl 7-fluoro-3-(4-methoxyphenyl)-2-(4-methylphenylsulfonamido)-1,2-dihydroisoquinolin-1-ylphosphonate | 1176334-82-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl 7-fluoro-3-(4-methoxyphenyl)-2-(4-methylphenylsulfonamido)-1,2-dihydroisoquinolin-1-ylphosphonate
• 英文别名: N-[1-[diethoxy(oxido)phosphaniumyl]-7-fluoro-3-(4-methoxyphenyl)-1H-isoquinolin-2-yl]-4-methylbenzenesulfonamide
• CAS: 1176334-82-9
• 化学式: C₂₇H₃₀FN₂O₆PS
• 分子量: 560.583
• InChiKey: GFVUGJIYFAXGHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  38
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  N-[[5-fluoro-2-[2-(4-methoxyphenyl)ethynyl]phenyl]methylideneamino]-4-methylbenzenesulfonamide 、 亚磷酸二乙酯 在 palladium diacetate 作用下， 以 甲苯 为溶剂， 以50%的产率得到diethyl 7-fluoro-3-(4-methoxyphenyl)-2-(4-methylphenylsulfonamido)-1,2-dihydroisoquinolin-1-ylphosphonate
  参考文献：
  名称：

  Lewis acid-catalyzed reactions of N′-(2-alkynylbenzylidene)hydrazides with diethyl phosphite

  摘要：

  Lewis acid catalyst-tuned reactions of N'-(2-alkynylbenzylidene)hydrazides with diethyl phosphite are described. Isoquinolin-1-ylphosphonate is generated when copper triflate is utilized as catalyst, while 2-amino-1,2-dihydroisoquinolin-1-ylphosphonate is obtained in the presence of palladium acetate. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.05.013

文献信息

• Lewis acid-catalyzed reactions of N′-(2-alkynylbenzylidene)hydrazides with diethyl phosphite
  作者：Xingxin Yu、Qiuping Ding、Zhiyuan Chen、Jie Wu

  DOI：10.1016/j.tetlet.2009.05.013

  日期：2009.7

  Lewis acid catalyst-tuned reactions of N'-(2-alkynylbenzylidene)hydrazides with diethyl phosphite are described. Isoquinolin-1-ylphosphonate is generated when copper triflate is utilized as catalyst, while 2-amino-1,2-dihydroisoquinolin-1-ylphosphonate is obtained in the presence of palladium acetate. (C) 2009 Elsevier Ltd. All rights reserved.