1-(3,4-Dimethyl-2,3-dihydro-pyrrol-1-yl)-butan-1-one | 60205-23-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(3,4-Dimethyl-2,3-dihydro-pyrrol-1-yl)-butan-1-one
• 英文别名: 1-(3,4-dimethyl-2,3-dihydropyrrol-1-yl)butan-1-one
• CAS: 60205-23-4
• 化学式: C₁₀H₁₇NO
• 分子量: 167.251
• InChiKey: QNLMRRGJNQSGEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N,N-Diallyl-butyramid 在 苄基三丁基溴化铵 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 以92%的产率得到1-(3,4-Dimethyl-2,3-dihydro-pyrrol-1-yl)-butan-1-one
  参考文献：
  名称：

  Highly regioselective synthesis of N-acyl-2,3-dihydropyrrole or N-sulfonyl-2,3-dihydropyrrole derivatives by nano-palladium catalyzed cycloisomerization of 1,6-dienes

  摘要：

  Porous palladium nanoparticles were prepared using a solution-phase approach. Their structures and shapes were analyzed by XRD, EDS, TEM and HRTEM. These palladium nanoparticles were used to catalyze the cycloisomerization reaction of N,N-diallylamide or N,N-diallylsulfonamide, and N-acyl-23-dihydropyrrole or N-sulfonyl-2,3-dihydropyrrole derivatives were therefore synthesized with very high regioselectivity, and in good yields. The nano-palladium catalyst showed high efficiency and it can be reused several times. A hydropalladation mechanism was proposed for this reaction. (C) 2009 Published by Elsevier B.V.

  DOI：

  10.1016/j.catcom.2009.12.018