N-[2-(5,6-dimethoxypyridin-2-yl)ethyl]-N-(4-phenylbutan-2-yl)-6-(propan2yl)pyridine-2-carboxamide | 1300587-65-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-[2-(5,6-dimethoxypyridin-2-yl)ethyl]-N-(4-phenylbutan-2-yl)-6-(propan2yl)pyridine-2-carboxamide
• 英文别名: N-[2-(5,6-dimethoxypyridin-2-yl)ethyl]-N-(4-phenylbutan-2-yl)-6-propan-2-ylpyridine-2-carboxamide
• CAS: 1300587-65-8
• 化学式: C₂₈H₃₅N₃O₃
• 分子量: 461.604
• InChiKey: KMNFAGBQNHMWAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] TERTIARY AMIDE OREXIN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE RÉCEPTEURS D'OREXINES AMIDES TERTIAIRES
  申请人：MERCK SHARP & DOHME

  公开号：WO2011053522A1

  公开（公告）日：2011-05-05

  The present invention is directed to tertiary amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及三级酰胺化合物，它们是促进素受体的拮抗剂，并且它们在治疗或预防神经和精神障碍和疾病中具有用处，其中促进素受体参与其中。本发明还涉及包含这些化合物的制药组合物，以及在预防或治疗促进素受体参与的这些疾病中使用这些化合物和组合物。
• TERTIARY AMIDE OREXIN RECEPTOR ANTAGONISTS
  申请人：Coleman Paul J.

  公开号：US20120196901A1

  公开（公告）日：2012-08-02

  The present invention is directed to tertiary amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

  本发明涉及三级酰胺化合物，其是促进睡眠激素受体的拮抗剂，可用于治疗或预防涉及促进睡眠激素受体的神经和精神障碍和疾病。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗涉及促进睡眠激素受体的疾病中使用这些化合物和组合物。
• Methods and pharmaceutical compositions for the treatment of cancer
  申请人：INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

  公开号：US10894042B2

  公开（公告）日：2021-01-19

  The present invention relates to methods and pharmaceutical compositions for the treatment of cancer. More particularly, the present invention relates to a method of treating cancer in subject in need thereof comprising administering the subject with a therapeutically effective amount of at least one OX1R antagonist.

  本发明涉及治疗癌症的方法和药物组合物。更具体地说，本发明涉及一种治疗有需要的受试者癌症的方法，该方法包括向受试者施用治疗有效量的至少一种 OX1R 拮抗剂。
• USE OF OX1R ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASES
  申请人：INSERM (Institut National de la Santé et de la Recherche Médicale)

  公开号：EP3223803A1

  公开（公告）日：2017-10-04
• METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CANCER
  申请人：INSERM (Institut National de la Santé et de la Recherche Médicale)

  公开号：EP3218007A1

  公开（公告）日：2017-09-20