4,7-dimethyl-1,2,3-tris-(4-methylbenzyl)-1H-indene | 1433220-02-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 4,7-dimethyl-1,2,3-tris-(4-methylbenzyl)-1H-indene
• 英文别名: 4,7-dimethyl-1,2,3-tris[(4-methylphenyl)methyl]-1H-indene
• CAS: 1433220-02-0
• 化学式: C₃₅H₃₆
• 分子量: 456.671
• InChiKey: WTJSZUDLEBCUCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  dicarbonyldichlororuthenium 、 4,7-dimethyl-1,2,3-tris-(4-methylbenzyl)-1H-indene 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 70.5h， 以40%的产率得到chlorodicarbonyl(η⁵-4,7-dimethyl-1,2,3-tris(4-methylbenzyl)indenyl)ruthenium(II)
  参考文献：
  名称：

  Cytotoxicities of Polysubstituted Chlorodicarbonyl(cyclopentadienyl) and (Indenyl)ruthenium Complexes

  摘要：

  Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (Indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.

  DOI：

  10.1021/om400234p
• 作为产物：
  描述：

  4-甲基苄基氯化镁 、 4,7-dimethyl-indan-2-one 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.17h， 生成 4,7-dimethyl-1,2,3-tris-(4-methylbenzyl)-1H-indene
  参考文献：
  名称：

  Cytotoxicities of Polysubstituted Chlorodicarbonyl(cyclopentadienyl) and (Indenyl)ruthenium Complexes

  摘要：

  Polysubstituted cyclopentadienyl and indenyl complexes of ruthenium were synthesized and investigated to elucidate their potential cytotoxic activities. In particular, substituted (Indenyl)ruthenium complexes inhibited the proliferation of a panel of human adherent cancer cells with comparable activity to reference agent cisplatin. One of the active compounds exerted a concentration dependent inhibition of cell cycle at G1-S transiton as evidenced by flow cytometry.

  DOI：

  10.1021/om400234p