Lithium, [bis(methylthio)methyl]- | 62762-69-0

• 分子结构分类: 有机化合物
• 英文名称: Lithium, [bis(methylthio)methyl]-
• 英文别名: bis(methylthio)methyllithium
• CAS: 62762-69-0
• 化学式: C₃H₇LiS₂
• 分子量: 114.162
• InChiKey: GRARYXSWCIZQFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.16
• 重原子数：
  6.0
• 可旋转键数：
  2.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  Lithium, [bis(methylthio)methyl]- 、 环丙甲醛 以76%的产率得到
  参考文献：
  名称：

  DENIS, J. N.;DESAUVAGE, S.;HEVESI, L.;KRIEF, A., TETRAHEDRON LETT., 1981, 22, N 40, 4009-4012

  摘要：

  DOI：

文献信息

• Bis[bis(methylthio)lithiomethyl]dimethylsilanes: A useful reagent for the synthesis of polysilacarbacycles via disilylation
  作者：Masaki Shimizu、Masayuki Iwakubo、Yasushi Nishihara、Tamejiro Hiyama

  DOI：10.1016/s0040-4039(98)00457-2

  日期：1998.5

  Bis[bis(methylthio)lithiomethyl]dimethylsilane was generated from bis[bis(methylthio)methyl]dimethylsilane by deprotonation with t-BuLi in THF and allowed to react with various dichloro(poly)silanes to give the corresponding 4- to 7-membered polysilacarbacycles in moderate to good yields. The methylthio groups in the cyclized products were readily removed by radical reduction with Bu3SnH.

  由双[双（甲硫基甲基）甲基]二甲基硅烷通过在THF中用t- BuLi去质子化反应制得双[双（甲硫基）锂硫基甲基]二甲基硅烷，并使其与各种二氯（聚）硅烷反应，得到相应的4至7元聚硅碳环化合物，产率中等至良好。通过用Bu 3 SnH进行自由基还原，可以容易地除去环化产物中的甲硫基。
• Inosose derivatives, production and use thereof
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05004838A1

  公开（公告）日：1991-04-02

  Disclosed is a novel inosose compound represented by the general formula: ##STR1## wherein X.sup.1 and X.sup.2 are both halogen; X.sup.1 is hydrogen and X.sup.2 is halogen; or X.sup.1 is --SQ.sup.1 and X.sup.2 is --SQ.sup.2 (each of Q.sup.1 and Q.sup.2 is lower alkyl or Q.sup.1 and Q.sup.2 may form lower alkylene), R.sup.1 is a protective group for hydroxyl and Y is .dbd.O, .dbd.N--Z (Z is hydroxyl which may be protected) or ##STR2## (A is hydrogen or an amine residue), particularly to the compound wherein the symbol Y is oxygen. The inosose compound is useful as intermediates for production of valiolamine and the N-substituted derivatives thereof, which have potent .alpha.-glucosidase inhibiting activities and are useful as preventives or therapeutics for symptoms of hyperglycemia and various diseases derived therefrom in human and animals, such as diabetes, obesity and hyperlipemia.

  本发明涉及一种新的肌醇糖化合物，其通式为：##STR1## 其中X.sup.1和X.sup.2均为卤素；X.sup.1为氢，X.sup.2为卤素；或者X.sup.1为--SQ.sup.1，X.sup.2为--SQ.sup.2（其中每个Q.sup.1和Q.sup.2为低级烷基，或Q.sup.1和Q.sup.2可形成低级烷基烯），R.sup.1是羟基的保护基，Y为.dbd.O，.dbd.N--Z（其中Z是可保护的羟基）或##STR2##（其中A是氢或胺基残基），特别是其中符号Y为氧的化合物。该肌醇糖化合物可用作生产瓦利奥拉胺及其N-取代衍生物的中间体，这些衍生物具有强效的α-葡萄糖苷酶抑制活性，并可用作人类和动物中由高血糖症状引起的各种疾病的预防或治疗，如糖尿病、肥胖症和高脂血症。
• Van der Klein; De Nooy; Van der Marel, Synthesis, 1991, # 5, p. 347 - 349
  作者：Van der Klein、De Nooy、Van der Marel、Van Boom

  DOI：——

  日期：——
• Buerstinghaus,R.; Seebach,D., Chemische Berichte, 1977, vol. 110, p. 841 - 851
  作者：Buerstinghaus,R.、Seebach,D.

  DOI：——

  日期：——
• First total synthesis of Lycopodium alkaloids of the magellanane group. Enantioselective total syntheses of (-)-magellanine and (+)-magellaninone
  作者：Gavin C. Hirst、Theodore O. Johnson、Larry E. Overman

  DOI：10.1021/ja00060a064

  日期：1993.4