3-(2,6-Diethyl-4-nitro-phenyl)-1H-quinazoline-2,4-dione | 519183-49-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(2,6-Diethyl-4-nitro-phenyl)-1H-quinazoline-2,4-dione
• 英文别名: 3-(2,6-diethyl-4-nitrophenyl)-1H-quinazoline-2,4-dione
• CAS: 519183-49-4
• 化学式: C₁₈H₁₇N₃O₄
• 分子量: 339.351
• InChiKey: VZZZSMTXDVZUFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  95.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(2,6-Diethyl-4-nitro-phenyl)-1H-quinazoline-2,4-dione 在 palladium on activated charcoal 吡啶 、 氢气 、 sodium hydride 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 生成 DAMPAQ-22
  参考文献：
  名称：

  Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells

  摘要：

  Non-peptide, small-molecular, non-competitive inhibitors of puromycin-sensitive aminopeptidase (PSA), that is, 3-(2,6-diethylphenyl)-2,4(1H,3 H)-quinazolinedione (PAQ-22, 3) and its 1N-methyl analogue (MPAQ-22 4), were structurally modified to afford fluorescent bioprobes, ANTAQ (5) and DAMPAQ-22 (6). The cellular localization of PSA could be visualized by the use of these fluorescent bioprobes. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00845-4
• 作为产物：
  描述：

  2,6-二乙基-4-硝基苯胺 在 sodium hydroxide 、 三乙胺 作用下， 以 乙醇 、 1,2-二氯乙烷 为溶剂， 生成 3-(2,6-Diethyl-4-nitro-phenyl)-1H-quinazoline-2,4-dione
  参考文献：
  名称：

  Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells

  摘要：

  Non-peptide, small-molecular, non-competitive inhibitors of puromycin-sensitive aminopeptidase (PSA), that is, 3-(2,6-diethylphenyl)-2,4(1H,3 H)-quinazolinedione (PAQ-22, 3) and its 1N-methyl analogue (MPAQ-22 4), were structurally modified to afford fluorescent bioprobes, ANTAQ (5) and DAMPAQ-22 (6). The cellular localization of PSA could be visualized by the use of these fluorescent bioprobes. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00845-4

文献信息

• Fluorescent bioprobes for visualization of puromycin-sensitive aminopeptidase in living cells
  作者：Hiroki Kakuta、Yukiko Koiso、Kazuo Nagasawa、Yuichi Hashimoto

  DOI：10.1016/s0960-894x(02)00845-4

  日期：2003.1

  Non-peptide, small-molecular, non-competitive inhibitors of puromycin-sensitive aminopeptidase (PSA), that is, 3-(2,6-diethylphenyl)-2,4(1H,3 H)-quinazolinedione (PAQ-22, 3) and its 1N-methyl analogue (MPAQ-22 4), were structurally modified to afford fluorescent bioprobes, ANTAQ (5) and DAMPAQ-22 (6). The cellular localization of PSA could be visualized by the use of these fluorescent bioprobes. (C) 2002 Elsevier Science Ltd. All rights reserved.