dimethylphosphorylthioformic acid pyrrolidide | 1021879-88-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: dimethylphosphorylthioformic acid pyrrolidide
• CAS: 1021879-88-8
• 化学式: C₇H₁₄NOPS
• 分子量: 191.234
• InChiKey: GSPRIWANROFBGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.99
• 重原子数：
  11.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  20.31
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  四氢吡咯 、 α-(dimethylphosphoryl)methyl 5-(1-phenyl)-1H-tetrazolyl sulfoxide 以 1,4-二氧六环 为溶剂， 反应 0.75h， 以52%的产率得到dimethylphosphorylthioformic acid pyrrolidide
  参考文献：
  名称：

  Thermolyses of α-phosphorylmethyl tetrazolyl sulfoxides in the presence of 2,3-dimethyl-1,3-butadiene and their reactions with several amines

  摘要：

  We have synthesized alpha-(phosphoryl)methyl tetrazolyl sulfoxides and examined the reactivities in the thermolyses and in the presence of several amines, such as aniline, benzylamine, piperidine, pyrrolidine, and morpholine. Thermolyses of the derivatives in the presence of 2,3-dimethyl-1,3-butadiene afforded 2-phosphoryl substituted 4,5-dimethyl-3,6-dihydro-2H-thiopyran S-oxide. In addition, novel phosphinecar-bothioamides were obtained in the reaction of the derivatives with amines. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.01.082