| 84666-32-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 84666-32-0
• 化学式: C₂₂H₃₈OSn
• 分子量: 437.253
• InChiKey: AHCZOCVRUQJDJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.15
• 重原子数：
  24
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-iodo-3-(methoxymethoxy)benzene 、 在 bis-triphenylphosphine-palladium(II) chloride 、 lithium chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以93%的产率得到1-(Methoxymethoxy)-3-(3-phenylmethoxyprop-1-en-2-yl)benzene
  参考文献：
  名称：

  Asymmetric synthesis of isobenzofuranone derivatives and their unique character as protein kinase Cα (PKCα) activators

  摘要：

  Efficient enantio-selective synthesis of conformationally constrained diacylglycerol analogues, 7-substituted isobenzofuranone derivatives, originally developed by us as PKC alpha ligands, was achieved by asymmetric dihydroxylation and gamma-lactone formation via ortho-lithiation and carboxylation. A series of derivatives having straight and/or branched side chains were synthesized and evaluated, and low-nanomolar-concentration affinity ligands and highly potent PKC alpha activators were found among them. These potent ligands induced phenotypic change of K562 cells, which is characteristic of PKC activators. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.069
• 作为产物：
  描述：

  dimethyl-phenyl-[(E)-3-phenylmethoxy-2-tributylstannylprop-1-enyl]silane 、 四丁基氟化铵 以77%的产率得到
  参考文献：
  名称：

  RITTER, KURT, SYNTHESIS (BRD),(1989) N, C. 218-221

  摘要：

  DOI：

文献信息

• Regioselective hydrostannations catalyzed by molybdenum isonitrile complexes
  作者：Sascha Braune、Uli Kazmaier

  DOI：10.1016/s0022-328x(01)01309-2

  日期：2002.1

  selectivities obtained with this catalyst are significantly higher in comparison to the results obtained with the commonly used palladium and rhodium catalysts. The influence of the isonitrile incorporated into the molybdenum complex is investigated.

  使用的Mo（CO）Hydrostannations 3（CN吨丁基）3产生α-stannylated醇和醚在一个高度选择性的方式。与通常使用的钯和铑催化剂获得的结果相比，用这种催化剂获得的产率和选择性明显更高。研究了掺入钼配合物中的异腈的影响。
• Miyake, Hideyoshi; Yamamura, Kimiaki, Chemistry Letters, 1989, p. 981 - 984
  作者：Miyake, Hideyoshi、Yamamura, Kimiaki

  DOI：——

  日期：——
• RITTER, KURT, SYNTHESIS (BRD),(1989) N, C. 218-221
  作者：RITTER, KURT

  DOI：——

  日期：——
• JUNG, M. E.;LIGHT, L. A., TETRAHEDRON LETT., 1982, 23, N 38, 3851-3854
  作者：JUNG, M. E.、LIGHT, L. A.

  DOI：——

  日期：——
• Asymmetric synthesis of isobenzofuranone derivatives and their unique character as protein kinase Cα (PKCα) activators
  作者：Go Hirai、Yosuke Ogoshi、Megumi Ohkubo、Yuki Tamura、Toru Watanabe、Tadashi Shimizu、Mikiko Sodeoka

  DOI：10.1016/j.tetlet.2009.03.069

  日期：2009.7

  Efficient enantio-selective synthesis of conformationally constrained diacylglycerol analogues, 7-substituted isobenzofuranone derivatives, originally developed by us as PKC alpha ligands, was achieved by asymmetric dihydroxylation and gamma-lactone formation via ortho-lithiation and carboxylation. A series of derivatives having straight and/or branched side chains were synthesized and evaluated, and low-nanomolar-concentration affinity ligands and highly potent PKC alpha activators were found among them. These potent ligands induced phenotypic change of K562 cells, which is characteristic of PKC activators. (C) 2009 Elsevier Ltd. All rights reserved.