tert-Butyl-dimethyl-((1R,2R)-1-methyl-2-phenyl-hex-5-enyloxy)-silane | 393109-08-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-Butyl-dimethyl-((1R,2R)-1-methyl-2-phenyl-hex-5-enyloxy)-silane
• 英文别名: tert-butyl-dimethyl-[(2R,3R)-3-phenylhept-6-en-2-yl]oxysilane
• CAS: 393109-08-5
• 化学式: C₁₉H₃₂OSi
• 分子量: 304.548
• InChiKey: YUSPJIATENNNMR-AEFFLSMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.15
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tert-Butyl-dimethyl-((1R,2R)-1-methyl-2-phenyl-hex-5-enyloxy)-silane 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 生成 (2R,5R,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-1-((2S,3S,4S)-3,4-dimethoxy-1-oxy-3,4-dihydro-2H-pyrrol-2-yl)-5-phenyl-heptan-2-ol
  参考文献：
  名称：

  Acceleration of hetero-Michael reaction by symmetrical pentacyclic guanidines

  摘要：

  Symmetrical pentacyclic guanidines 1a-c and 2 which contain the core skeleton of 13,14,15-isocrmbescidine 800, have been synthesized. In the presence of catalytic amounts of these guanidines 1, the reaction rate of the conjugate addition of pyrrolidine (9) to gamma -crotonolactone (10) could be enhanced depending upon the size of the cavities and substituents on tetrahydropyran rings of 1 and 2. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00907-3
• 作为产物：
  描述：

  生成 tert-Butyl-dimethyl-((1R,2R)-1-methyl-2-phenyl-hex-5-enyloxy)-silane
  参考文献：
  名称：

  Acceleration of hetero-Michael reaction by symmetrical pentacyclic guanidines

  摘要：

  Symmetrical pentacyclic guanidines 1a-c and 2 which contain the core skeleton of 13,14,15-isocrmbescidine 800, have been synthesized. In the presence of catalytic amounts of these guanidines 1, the reaction rate of the conjugate addition of pyrrolidine (9) to gamma -crotonolactone (10) could be enhanced depending upon the size of the cavities and substituents on tetrahydropyran rings of 1 and 2. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00907-3

文献信息

• Acceleration of hetero-Michael reaction by symmetrical pentacyclic guanidines
  作者：Kazuo Nagasawa、Angelina Georgieva、Hiroki Takahashi、Tadashi Nakata

  DOI：10.1016/s0040-4020(01)00907-3

  日期：2001.10

  Symmetrical pentacyclic guanidines 1a-c and 2 which contain the core skeleton of 13,14,15-isocrmbescidine 800, have been synthesized. In the presence of catalytic amounts of these guanidines 1, the reaction rate of the conjugate addition of pyrrolidine (9) to gamma -crotonolactone (10) could be enhanced depending upon the size of the cavities and substituents on tetrahydropyran rings of 1 and 2. (C) 2001 Elsevier Science Ltd. All rights reserved.