methyl 4-(2-bromo-4-fluorophenyl)-2-(thiazol-2-yl)-6-(4-morpholinylmethy)-1,4-dihydropyrimidine-5-carboxylic ester | 1094603-15-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: methyl 4-(2-bromo-4-fluorophenyl)-2-(thiazol-2-yl)-6-(4-morpholinylmethy)-1,4-dihydropyrimidine-5-carboxylic ester
• 英文别名: Methyl 4-(2-bromo-4-fluorophenyl)-6-(morpholin-4-ylmethyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate
• CAS: 1094603-15-2
• 化学式: C₂₀H₂₀BrFN₄O₃S
• 分子量: 495.372
• InChiKey: ZIGBVTIJGLEPKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• BROMO-PHENYL SUBSTITUTED THIAZOLYL DIHYDROPYRIMIDINES
  申请人：Siegfried Goldmann

  公开号：US20100240655A1

  公开（公告）日：2010-09-23

  Bromo-phenyl substituted thiazolyl dihydropyrimidines and combinations thereof with other antiviral agents for combating HBV infections.

  Bromo-苯基取代的噻唑二氢嘧啶及其与其他抗病毒药物的组合，用于对抗HBV感染。
• PROCESSES FOR PREPARING DIHYDROPYRIMIDINE DERIVATIVES AND INTERMEDIATES THEREOF
  申请人：SUNSHINE LAKE PHARMA CO., LTD.

  公开号：US20160244438A1

  公开（公告）日：2016-08-25

  The present invention relates to processes for preparing a dihydropyrimidine derivative having Formula (I) or a tautomer thereof having Formula (Ia), as well as a intermediate thereof. The processes of the invention have simple operation, high optical purity of product, high yield and convenient work-up, which is suitable for industrial production.

  本发明涉及制备具有式(I)的二氢嘧啶衍生物或具有式(Ia)的其互变异构体以及其中间体的方法。本发明的方法操作简单，产物的光学纯度高，收率高且操作方便，适合于工业生产。
• Bromo-phenyl substituted thiazolyl dihydropyrimidines
  申请人：Sunshine Lake Pharma Co., Ltd

  公开号：EP2514750A1

  公开（公告）日：2012-10-24

  This invention relates to a bromo-phenyl substituted thiazolyl dihydropyrimidine, its preparation method and use as a medicament for treating and preventing hepatitis B infections. The invention also relates to a composition comprising the dihydropyrimidine, one or more antiviral agents and, optionally, an immunomodulator for treating and preventing HBV infections.

  本发明涉及一种溴苯基取代的噻唑基二氢嘧啶、其制备方法以及作为治疗和预防乙型肝炎感染药物的用途。本发明还涉及一种组合物，该组合物包含二氢嘧啶、一种或多种抗病毒剂，以及可选的免疫调节剂，用于治疗和预防 HBV 感染。
• 2,4,5,6-Substituted 3,6-dihydropyrimidine derivatives as hepatitis B virus (HBV) polymerase inhibitors for the treatment of e.g. chronic hepatitis
  申请人：Sunshine Lake Pharma Co., Ltd.

  公开号：EP2888241B1

  公开（公告）日：2017-07-12
• DIHYDROPYRIMIDINE COMPOUNDS AND THEIR APPLICATION IN PHARMACEUTICALS
  申请人：North & South Brother Pharmacy Investment Company Limited

  公开号：EP3122747B1

  公开（公告）日：2020-05-20